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八段锦干预对轻度认知障碍老年人跌倒风险的影响:一项随机对照试验研究方案。

Effect of a Baduanjin intervention on the risk of falls in the elderly individuals with mild cognitive impairment: a study protocol for a randomized controlled trial.

机构信息

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.

Department of Rehabilitation,The People's Hospital of Baoan Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, 518101, China.

出版信息

BMC Complement Med Ther. 2023 Jul 13;23(1):233. doi: 10.1186/s12906-023-04050-4.


DOI:10.1186/s12906-023-04050-4
PMID:37442990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10347860/
Abstract

BACKGROUND: Falls are a global public problem and may be an important cause of death in older adults. However, older adults with mild cognitive impairment(MCI) are more likely to fall and suffer more damage than older adults with normal cognitive function, which shows the importance of preventing falls. More and more evidence shows that Baduanjin can improve the balance function of the elderly and reduce the risk of falls in the elderly with MCI, but the mechanism is still unclear. The main purpose of this study is to verify the intervention effect of Baduanjin training on the risk of falls in elderly people with MCI and to elucidate the underlying mechanism of Baduanjin training in reducing the risk of falls in MCI patients. METHODS: In this prospective study, outcome assessor-blind, three-arm randomized controlled trial, a total of 72 eligible participants will be randomly allocated (1:1:1) into the 12-week Baduanjin exercise intervention (60 min per session, three sessions per week), the 12-week brisk walking group(60 min per session, three sessions per week) or the 12-week health education group. Primary outcome is the Fall-Risk Self-Assessment Questionnaire(FRQ), and secondary outcomes are fall efficacy index, gait assessment, balance function, lower limb muscle strength, cognitive function, activities of daily living(ADL) and MRI scans. In addition to the MRI scans, which will be measured before and after the intervention,other primary and secondary outcomes will be assessed at baseline, 6 weeks, and 12 weeks (at the end of the intervention) and after an additional 12-week follow-up period. The mixed linear model will be conducted to observe the intervention effects. DISCUSSION: This trial will investigate the effect of Baduanjin exercise on the prevention of falls in elderly individuals with MCI, explore the imaging mechanism of Baduanjin exercise to reduce the risk of falls in elderly individuals with MCI from the perspective of vestibular neural network, and provide strong evidence for Baduanjin exercise to reduce the risk of falls in elderly individuals with MCI, as well as provide new ideas and approaches for the central mechanism of Traditional Chinese Medicine(TRC) rehabilitation methods to intervene in falls in elderly. TRIAL REGISTRATION: Chictr.org.cn, ID: ChiCTR2200057520. Registered on 14 March 2022, https://www.chictr.org.cn/showproj.html?proj=146592 .

摘要

背景:跌倒在全球范围内是一个公共问题,可能是老年人死亡的一个重要原因。然而,与认知功能正常的老年人相比,轻度认知障碍(MCI)的老年人更容易跌倒,且损伤更严重,这表明预防跌倒的重要性。越来越多的证据表明,八段锦可以改善老年人的平衡功能,降低 MCI 老年人跌倒的风险,但机制尚不清楚。本研究的主要目的是验证八段锦训练对 MCI 老年人跌倒风险的干预效果,并阐明八段锦训练降低 MCI 患者跌倒风险的潜在机制。

方法:在这项前瞻性研究中,采用结局评估者盲法、三臂随机对照试验,共纳入 72 名符合条件的参与者,按照 1:1:1 的比例随机分配到 12 周八段锦运动干预组(每次 60 分钟,每周 3 次)、12 周快走组(每次 60 分钟,每周 3 次)或 12 周健康教育组。主要结局指标为跌倒风险自我评估问卷(FRQ),次要结局指标为跌倒效能指数、步态评估、平衡功能、下肢肌肉力量、认知功能、日常生活活动(ADL)和 MRI 扫描。除了在干预前后进行 MRI 扫描外,其他主要和次要结局指标将在基线、6 周和 12 周(干预结束时)以及额外的 12 周随访期进行评估。采用混合线性模型观察干预效果。

讨论:本试验将研究八段锦运动对预防 MCI 老年人跌倒的效果,从前庭神经网络的角度探讨八段锦运动降低 MCI 老年人跌倒风险的影像学机制,为八段锦运动降低 MCI 老年人跌倒风险提供有力证据,为中医药康复方法干预老年人跌倒的中枢机制提供新的思路和方法。

试验注册:Chictr.org.cn,ID:ChiCTR2200057520。于 2022 年 3 月 14 日注册,https://www.chictr.org.cn/showproj.html?proj=146592。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/10347860/6f6a8f1251dc/12906_2023_4050_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/10347860/ac19d70d5b9f/12906_2023_4050_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/10347860/6f6a8f1251dc/12906_2023_4050_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/10347860/ac19d70d5b9f/12906_2023_4050_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/10347860/6f6a8f1251dc/12906_2023_4050_Fig2_HTML.jpg

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引用本文的文献

[1]
The effect of Baduanjin exercise training on balance and fall risk in elderly individuals: A randomized controlled trial.

Medicine (Baltimore). 2025-5-2

[2]
Effectiveness of a brain exercise program using game-based cognitive enhancement to reduce mild cognitive impairment among older adults in Pathum Thani Province, Thailand: a quasi-experimental study.

Osong Public Health Res Perspect. 2025-2

本文引用的文献

[1]
Alterations in Corticocortical Vestibular Network Functional Connectivity Are Associated with Decreased Balance Ability in Elderly Individuals with Mild Cognitive Impairment.

Brain Sci. 2022-12-29

[2]
Association Between Fatigue and Falls Risk Among the Elderly Aged Over 75 Years in China: The Chain Mediating Role of Falls Efficacy and Lower Limb Function.

Front Public Health. 2022

[3]
Altered Functional Connectivity and Sensory Processing in Blepharospasm and Hemifacial Spasm: Coexistence and Difference.

Front Neurol. 2021-12-15

[4]
Baduanjin Exercise for Adults Aged 65 Years and Older: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

J Appl Gerontol. 2022-4

[5]
Mind-Body Exercise Modulates Locus Coeruleus and Ventral Tegmental Area Functional Connectivity in Individuals With Mild Cognitive Impairment.

Front Aging Neurosci. 2021-6-14

[6]
Effect of Baduanjin exercise on the cognitive function of middle-aged and older adults: A systematic review and meta-analysis.

Complement Ther Med. 2021-6

[7]
Baduanjin Qigong Improves Balance, Leg Strength, and Mobility in Individuals With Chronic Stroke: A Randomized Controlled Study.

Neurorehabil Neural Repair. 2021-5

[8]
Effects of traditional Chinese exercise on patients with cognitive impairment: A systematic review and Bayesian network meta-analysis.

Nurs Open. 2021-9

[9]
The human corticocortical vestibular network.

Neuroimage. 2020-12

[10]
Effects of a traditional Chinese mind-body exercise, Baduanjin, on the physical and cognitive functions in the community of older adults with cognitive frailty: study protocol for a randomised controlled trial.

BMJ Open. 2020-4-15

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