Mount Carmel Health Systems, Division of Genetic and Genomic Medicine, Nationwide Children's Hospital, Columbus, Ohio.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas McGovern Medical School, Houston, Texas.
Clin Obstet Gynecol. 2023 Sep 1;66(3):607-615. doi: 10.1097/GRF.0000000000000800. Epub 2023 Jul 14.
Cell-free circulating DNA is an evolving technology with important clinical applications in both obstetric care and oncology. In the challenging patient with pregnancy and co-existing malignancy, the utility of cell-free DNA both for aneuploidy screening and cancer identification is an area of active research. Understanding the physiology associated with circulating cell-free DNA and subsequent laboratory evaluation is critical for clinicians caring for the obstetric patient with cell-free fetal DNA screening results suggestive of malignancy. Ongoing research is necessary to determine best practices for the evaluation and management of these patients with promising applications in the advancement of precision medicine.
游离循环 DNA 是一项不断发展的技术，在产科护理和肿瘤学领域具有重要的临床应用。在妊娠合并恶性肿瘤的具有挑战性的患者中，游离 DNA 用于非整倍体筛查和癌症识别的实用性是一个活跃的研究领域。了解与循环游离 DNA 相关的生理学及其后续实验室评估对于照顾接受游离胎儿 DNA 筛查结果提示恶性肿瘤的产科患者的临床医生至关重要。需要开展进一步的研究来确定评估和管理这些患者的最佳实践，这些患者在精准医学的应用方面具有广阔的前景。
