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改良版Lung-RADS在评估既往有恶性肿瘤患者肺结节中的应用建议:一项初步研究。

Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study.

作者信息

Song Feipeng, Fu Binjie, Liu Mengxi, Liu Xiangling, Liu Sizhu, Lv Fajin

机构信息

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1 YouYi Road, Chongqing 400010, China.

出版信息

Diagnostics (Basel). 2023 Jun 29;13(13):2210. doi: 10.3390/diagnostics13132210.


DOI:10.3390/diagnostics13132210
PMID:37443604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10340214/
Abstract

BACKGROUND: In addition to the diameters of pulmonary nodules, the number and morphology of blood vessels in pure ground-glass nodules (pGGNs) were closely related to the occurrence of lung cancer. Moreover, the benign and malignant signs of nodules were also valuable for the identification of nodules. Based on these two points, we tried to revise Lung-RADS 2022 and proposed our Modified Lung-RADS. The aim of the study was to verify the diagnostic performance of Modified Lung-RADS for pulmonary solid nodules (SNs) and pure ground-glass nodules (pGGNs) in patients with previous malignancies. METHODS: The chest CT and clinical data of patients with prior cancer who underwent pulmonary nodulectomies from 1 January 2018 to 30 November 2021 were enrolled according to inclusion and exclusion criteria. A total of 240 patients with 293 pulmonary nodules were included in this study. In contrast with the original version, the risk classification of pGGNs based on the GGN-vascular relationships (GVRs), and the SNs without burrs and with benign signs, could be downgraded to category 2. The sensitivity, specificity, and agreement rate of the original Lung-RADS 2022 and Modified Lung-RADS for pGGNs and SNs were calculated and compared. RESULTS: Compared with the original version, the sensitivity and agreement rate of the Modified version for pGGNs increased from 0 and 23.33% to 97.10% and 92.22%, respectively, while the specificity decreased from 100% to 76.19%. As regards SNs, the specificity and agreement rate of the Modified version increased from 44.44% to 75.00% ( < 0.05) and 88.67% to 94.09% ( = 0.052), respectively, while the sensitivity was unchanged (98.20%). CONCLUSIONS: In general, the diagnostic efficiency of Modified Lung-RADS was superior to that of the original version, and Modified Lung-RADS could be a preliminary attempt to improve Lung-RADS 2022.

摘要

背景:除肺结节直径外,纯磨玻璃结节(pGGN)中血管的数量和形态与肺癌的发生密切相关。此外,结节的良恶性征象对结节的鉴别也具有重要价值。基于这两点,我们尝试对《肺癌影像报告和数据系统(Lung-RADS)2022》进行修订,并提出了我们的改良版Lung-RADS。本研究的目的是验证改良版Lung-RADS对既往有恶性肿瘤患者的肺实性结节(SN)和纯磨玻璃结节(pGGN)的诊断性能。 方法:根据纳入和排除标准,纳入2018年1月1日至2021年11月30日期间接受肺结节切除术的既往有癌症患者的胸部CT和临床资料。本研究共纳入240例患者的293个肺结节。与原版相比,基于GGN-血管关系(GVR)的pGGN以及无毛刺且具有良性征象的SN的风险分类可降至2类。计算并比较原版Lung-RADS 2022和改良版Lung-RADS对pGGN和SN的敏感性、特异性及符合率。 结果:与原版相比,改良版对pGGN的敏感性和符合率分别从0和23.33%提高到97.10%和92.22%,而特异性从100%降至76.19%。对于SN,改良版的特异性和符合率分别从44.44%提高到75.00%(<0.05)和88.67%提高到94.09%(=0.052),而敏感性不变(98.20%)。 结论:总体而言,改良版Lung-RADS的诊断效率优于原版,改良版Lung-RADS可能是改进Lung-RADS 2022的初步尝试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/4feed7d9e753/diagnostics-13-02210-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/74c26e1d65b1/diagnostics-13-02210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/c2f150087e8c/diagnostics-13-02210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/1e5ecdc1b5f6/diagnostics-13-02210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/318740ec440c/diagnostics-13-02210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/4feed7d9e753/diagnostics-13-02210-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/74c26e1d65b1/diagnostics-13-02210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/c2f150087e8c/diagnostics-13-02210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/1e5ecdc1b5f6/diagnostics-13-02210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/318740ec440c/diagnostics-13-02210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b71/10340214/4feed7d9e753/diagnostics-13-02210-g005.jpg

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引用本文的文献

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Subpleural pulmonary nodule marking with patent blue V dye prior to surgical resection.

Front Oncol. 2024-5-21

本文引用的文献

[1]
Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT.

Front Oncol. 2022-9-15

[2]
Application of CT Postprocessing Reconstruction Technique in Differential Diagnosis of Benign and Malignant Solitary Pulmonary Nodules and Analysis of Risk Factors.

Comput Math Methods Med. 2022

[3]
Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study.

Interact Cardiovasc Thorac Surg. 2022-6-15

[4]
Cancer statistics in China and United States, 2022: profiles, trends, and determinants.

Chin Med J (Engl). 2022-2-9

[5]
Evaluating the Patient With a Pulmonary Nodule: A Review.

JAMA. 2022-1-18

[6]
Cancer statistics, 2022.

CA Cancer J Clin. 2022-1

[7]
Cancer Risk in Nodules Detected at Follow-Up Lung Cancer Screening CT.

AJR Am J Roentgenol. 2022-4

[8]
Previous Extrapulmonary Malignancies Impact Outcomes in Patients With Surgically Resected Lung Cancer.

Front Surg. 2021-10-5

[9]
The ever-increasing importance of cancer as a leading cause of premature death worldwide.

Cancer. 2021-8-15

[10]
Effectiveness of radiologist training in improving reader agreement for Lung-RADS 4X categorization.

Eur Radiol. 2021-11

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