亚马孙草药疗法可减少肾脏的缺血再灌注损伤。

Amazonia Phytotherapy Reduces Ischemia and Reperfusion Injury in the Kidneys.

机构信息

School of Nursing, University of São Paulo, São Paulo 05403-000, Brazil.

Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.

出版信息

Cells. 2023 Jun 22;12(13):1688. doi: 10.3390/cells12131688.

Abstract

Acute kidney injury (AKI) is defined as a sudden decrease in kidney function. Phytomedicines have shown positive effects in the treatment of AKI worldwide. The aim of this study was to evaluate the effect of on the renal function of rats submitted to AKI. A phytochemical study of the plant was performed through liquid chromatography coupled with mass spectrometry (CL-EM) and DPPH and ABTS antioxidant tests. Renal function tests were performed in 20 male adult Wistar rats weighing from 250 to 300 g distributed in the following groups: SHAM (submitted to laparotomy with simulation of renal ischemia); ABUTA (animals that received 400 mg/kg of AG, orally-VO, once a day, for 5 days, with simulation of renal ischemia); I/N (animals submitted to laparotomy for clamping of bilateral renal pedicles for 30 min, followed by reperfusion); ABUTA + I/R (animals that received AG-400 mg/kg, 1× per day, VO, for 5 days, submitted to renal ischemia after treatment with herbal medicine). The results suggest that the consumption of promoted renoprotection, preventing the reduction of renal function induced by ischemia, oxidizing activity, and deleterious effects on the renal tissue, confirmed by the decrease of oxidative metabolites and increase of antioxidants in the animals' organisms.

摘要

急性肾损伤 (AKI) 定义为肾功能的突然下降。植物药已在全球范围内显示出对 AKI 治疗的积极作用。本研究的目的是评估 对 AKI 大鼠肾功能的影响。通过液相色谱-质谱联用 (CL-EM) 和 DPPH 和 ABTS 抗氧化试验对植物进行了植物化学研究。在 20 只雄性成年 Wistar 大鼠中进行了肾功能试验,这些大鼠体重为 250 至 300 克,分为以下几组:SHAM(接受剖腹手术,模拟肾缺血);ABUTA(每天口服 400mg/kg 的 AG,连续 5 天,模拟肾缺血);I/N(接受双侧肾蒂夹闭 30 分钟的剖腹手术,然后再灌注);ABUTA + I/R(给予 AG-400mg/kg,每天 1 次,口服,连续 5 天,在给予草药治疗后进行肾缺血)。结果表明, 的消耗促进了肾保护,防止了缺血引起的肾功能下降、氧化活性和对肾组织的有害影响,这通过动物体内氧化代谢物的减少和抗氧化剂的增加得到了证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a1/10341095/751ceab05cdb/cells-12-01688-g001.jpg

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