Nephrology Division, Department of Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Intern Med. 2022 May;37(3):534-550. doi: 10.3904/kjim.2021.526. Epub 2022 Apr 28.
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicated in the pathogenesis of ischemic AKI. Among various intrarenal immune cells, T cells play major roles in the injury process and in the repair mechanism affecting AKI to chronic kidney disease transition. Importantly, T cells also participate in distant organ crosstalk during AKI, which affects the overall outcomes. Therefore, targeting T cell-mediated pathways and T cell-based therapies have therapeutic promise for ischemic AKI. Here, we review the major populations of kidney T cells and their roles in ischemic AKI.
缺血性急性肾损伤（AKI）是一个常见的医学问题，具有显著的死亡率和发病率，影响全球大量患者。缺血性 AKI 与肾内炎症以及全身炎症有关；因此，先天和适应性免疫系统与缺血性 AKI 的发病机制有关。在各种肾内免疫细胞中，T 细胞在损伤过程中和影响 AKI 向慢性肾脏病转变的修复机制中发挥主要作用。重要的是，T 细胞在 AKI 期间也参与远处器官的串扰，从而影响整体结果。因此，针对 T 细胞介导的途径和基于 T 细胞的治疗方法具有治疗缺血性 AKI 的潜力。在这里，我们回顾了肾脏 T 细胞的主要群体及其在缺血性 AKI 中的作用。
