Kciuk Mateusz, Yahya Esam Bashir, Mohamed Montaha Mohamed Ibrahim, Abdulsamad Muhanad A, Allaq Abdulmutalib A, Gielecińska Adrianna, Kontek Renata
Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.
Doctoral School of Exact and Natural Sciences, University of Lodz, 90-237 Lodz, Poland.
Cancers (Basel). 2023 Jun 22;15(13):3298. doi: 10.3390/cancers15133298.
Accumulating evidence supports that both long non-coding and micro RNAs (lncRNAs and miRNAs) are implicated in glioma tumorigenesis and progression. Poor outcome of gliomas has been linked to late-stage diagnosis and mostly ineffectiveness of conventional treatment due to low knowledge about the early stage of gliomas, which are not possible to observe with conventional diagnostic approaches. The past few years witnessed a revolutionary advance in biotechnology and neuroscience with the understanding of tumor-related molecules, including non-coding RNAs that are involved in the angiogenesis and progression of glioma cells and thus are used as prognostic biomarkers as well as novel therapeutic targets. The emerging research on lncRNAs and miRNAs highlights their crucial role in glioma progression, offering new insights into the disease. These non-coding RNAs hold significant potential as novel therapeutic targets, paving the way for innovative treatment approaches against glioma. This review encompasses a comprehensive discussion about the role of lncRNAs and miRNAs in gene regulation that is responsible for the promotion or the inhibition of glioma progression and collects the existing links between these key cancer-related molecules.
越来越多的证据表明，长链非编码RNA和微小RNA（lncRNA和miRNA）均与胶质瘤的发生和发展有关。胶质瘤预后不佳与晚期诊断以及传统治疗大多无效有关，这是由于对胶质瘤早期阶段了解不足，而传统诊断方法无法观察到这些早期阶段。在过去几年中，随着对肿瘤相关分子的认识，生物技术和神经科学取得了革命性进展，其中包括参与胶质瘤细胞血管生成和进展的非编码RNA，因此它们被用作预后生物标志物以及新的治疗靶点。关于lncRNA和miRNA的新兴研究突出了它们在胶质瘤进展中的关键作用，为该疾病提供了新的见解。这些非编码RNA作为新的治疗靶点具有巨大潜力，为对抗胶质瘤的创新治疗方法铺平了道路。本综述全面讨论了lncRNA和miRNA在基因调控中的作用，这些作用导致了胶质瘤进展的促进或抑制，并收集了这些关键癌症相关分子之间的现有联系。
