Falco Michał, Masojć Bartłomiej, Sulikowski Tadeusz
Radiation Oncology Department, West Pomeranian Oncology Center, Strzałowska 22, 71-730 Szczecin, Poland.
Hospicjum Św. Jana Ewnagelisty, Pokoju 77, 71-740 Szczecin, Poland.
Cancers (Basel). 2023 Jun 28;15(13):3382. doi: 10.3390/cancers15133382.
The diagnosis rate of pancreatic cancer is steadily increasing. The average age of onset is close to 70 years. In most cases, the disease is diagnosed at an advanced stage. The indications for and techniques of radiotherapy are changing over time. The aim of this thesis is to present the role and possibilities of radiotherapy from the perspective of radiation oncologist. The most common cause of treatment failure in pancreatic cancer remains generalisation. The implementation of new systemic treatment regimens contributes to improved treatment outcomes regardless of the stage of the disease. With improved treatment outcomes in terms of the incidence of distant metastases, the impact of local curability on the length and quality of life of patients increases. Modern radiotherapy offers the opportunity to achieve high local cure rates. Postoperative radiotherapy in combination with chemotherapy seems justified in the group of postoperative pancreatic cancer patients with pT3 and pN+ features. In the group of patients with borderline resectable pancreatic cancer, the impact of radiotherapy in combination with the latest chemotherapy regimens is difficult to define clearly. In the setting of a diagnosis of advanced pancreatic cancer, radiotherapy, especially stereotactic radiotherapy, in combination with chemotherapy, contributes to improved local curability and allows to achieve a significantly reduced level of pain.
胰腺癌的诊断率正在稳步上升。发病的平均年龄接近70岁。在大多数情况下，该疾病在晚期被诊断出来。放射治疗的适应症和技术随着时间的推移而不断变化。本论文的目的是从放射肿瘤学家的角度阐述放射治疗的作用和可能性。胰腺癌治疗失败的最常见原因仍然是转移。新的全身治疗方案的实施有助于改善治疗结果，无论疾病处于何种阶段。随着远处转移发生率方面治疗结果的改善，局部治愈率对患者生存时间和生活质量的影响增加。现代放射治疗提供了实现高局部治愈率的机会。对于具有pT3和pN+特征的术后胰腺癌患者，术后放疗联合化疗似乎是合理的。在边缘可切除胰腺癌患者组中，放疗联合最新化疗方案的影响难以明确界定。在晚期胰腺癌的诊断背景下，放疗，尤其是立体定向放疗，联合化疗有助于提高局部治愈率，并能显著降低疼痛程度。
