Kim Chulho, Yu Hyunjae, Kim Dong-Kyu
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Republic of Korea.
Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Cancers (Basel). 2023 Jul 5;15(13):3503. doi: 10.3390/cancers15133503.
Several studies have shown that head and neck cancer is associated with an increased risk of stroke incidence. However, investigations of the association between the two diseases based on a matching cohort dataset are still limited. Therefore, we identified the incidence and risk of stroke in patients with head and neck cancer using a nationwide population-based cohort dataset. A total of 5248 individuals without cancer and 1312 with cancer were enrolled from the dataset after a 4:1 propensity score matching. We found that the incidence of overall stroke (per 1000 person years) was 19.29 for those with head and neck cancer, consisting of 17.32 as ischemic type and 2.74 as hemorrhagic type. Additionally, patients with head and neck cancer had a significantly increased risk of overall and ischemic stroke development but not hemorrhagic stroke. Moreover, the risk of stroke development over time was relatively high within the first year after the diagnosis of head and neck cancer. However, in the subgroup analysis, oral cavity cancer survivors showed an increased risk of both ischemic and hemorrhagic strokes. Therefore, our nationwide population-based cohort study suggests that clinicians should closely monitor patients with head and neck cancers for the early detection of stroke.
多项研究表明，头颈癌与中风发病率的增加有关。然而，基于匹配队列数据集对这两种疾病之间关联的调查仍然有限。因此，我们使用全国性的基于人群的队列数据集确定了头颈癌患者中风的发病率和风险。在进行4:1倾向评分匹配后，从数据集中共纳入了5248名无癌症个体和1312名癌症患者。我们发现，头颈癌患者的总体中风发病率（每1000人年）为19.29，其中缺血性中风为17.32，出血性中风为2.74。此外，头颈癌患者发生总体中风和缺血性中风的风险显著增加，但出血性中风风险未增加。而且，在头颈癌诊断后的第一年内，中风发生的风险相对较高。然而，在亚组分析中，口腔癌幸存者发生缺血性和出血性中风的风险均增加。因此，我们基于全国人群的队列研究表明，临床医生应密切监测头颈癌患者，以便早期发现中风。
