Gesualdo Carlo, Rossi Settimio, Iodice Clemente Maria, Rosolia Andrea, Melillo Paolo, Della Corte Michele, Simonelli Francesca
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via S. Pansini, 5, 80131 Naples, Italy.
J Clin Med. 2023 Jul 2;12(13):4449. doi: 10.3390/jcm12134449.
To perform a multimodal assessment of the ectopic inner foveal layers' (EIFL) prognostic role on idiopathic epiretinal membrane (ERM) surgery.
We retrospectively followed-up for 12 months 27 patients who underwent ERM surgery and stratified them based on EIFL presence (group 1) or absence (group 2) at baseline. Central Retinal Thickness (CRT) and best-corrected visual acuity (BCVA) were compared pre- and post-operatively at 1, 4 and 12 months, whereas fixation stability (FS), macular sensitivity (MS) and multifocal electroretinogram (mfERG) responses were confronted at baseline and 12 months.
In group 1, BCVA improved at 4 and 12 months (MD = 0.14 (SE = 0.04); MD = 0.13 (SE = 0.05), respectively) as well as in group 2 (MD = 0.31 (SE = 0.07); MD = 0.41 (SE = 0.08), respectively). CRT did not change in group 1, whereas it decreased in group 2 at 4 and 12 months (MD = -73.13; SE = 23.56; MD = -76.20; SE = 23.56). MS showed no changes in both groups after surgery. FS did not change in group 1, whereas group 2 improved FS 2° (+8.91 ± 13.97) and FS 4° (+4.33 ± 3.84). MfERG P1 wave did not change in group 1, while in group 2 αP1-2, αP1-3 and αP1-4 improved postoperatively (27.97 ± 27.62; 12.51 ± 17.36; 10.49 ± 17.19, respectively).
Multimodal assessment confirmed that EIFL negatively affected ERM surgery outcomes.
对特发性视网膜前膜（ERM）手术中异位中央凹内层（EIFL）的预后作用进行多模式评估。
我们对27例行ERM手术的患者进行了12个月的回顾性随访，并根据基线时是否存在EIFL将他们分为两组（第1组有EIFL，第2组无EIFL）。比较术前及术后1个月、4个月和12个月时的中心视网膜厚度（CRT）和最佳矫正视力（BCVA），同时对比基线和12个月时的注视稳定性（FS）、黄斑敏感度（MS）及多焦视网膜电图（mfERG）反应。
在第1组中，4个月和12个月时BCVA均有改善（平均差值分别为0.14（标准误 = 0.04）；0.13（标准误 = 0.05）），第2组同样如此（平均差值分别为0.31（标准误 = 0.07）；0.41（标准误 = 0.08））。第1组的CRT无变化，而第2组在4个月和12个月时CRT下降（平均差值 = -73.13；标准误 = 23.56；平均差值 = -76.20；标准误 = 23.56）。两组术后MS均无变化。第1组的FS无变化，而第2组的FS在2°（+8.91±13.97）和4°（+4.33±3.84）处有所改善。第1组的mfERG P1波无变化，而第2组术后αP1 - 2、αP1 - 3和αP1 - 4改善（分别为27.97±27.62；12.51±17.36；10.49±17.19）。
多模式评估证实EIFL对ERM手术结果有负面影响。
