Neurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Int J Mol Sci. 2023 Jun 27;24(13):10736. doi: 10.3390/ijms241310736.
Animals are required to handle daily massive amounts of information in an ever-changing environment, and the resulting memories and experiences determine their survival and development, which is critical for adaptive evolution. However, intrinsic forgetting, which actively deletes irrelevant information, is equally important for memory acquisition and consolidation. Recently, it has been shown that Rac1 activity plays a key role in intrinsic forgetting, maintaining the balance of the brain's memory management system in a controlled manner. In addition, dysfunctions of Rac1-dependent intrinsic forgetting may contribute to memory deficits in neurological and neurodegenerative diseases. Here, these new findings will provide insights into the neurobiology of memory and forgetting, pathological mechanisms and potential therapies for brain disorders that alter intrinsic forgetting mechanisms.
动物在不断变化的环境中需要处理日常大量的信息，由此产生的记忆和经验决定了它们的生存和发展，这对适应进化至关重要。然而，主动删除不相关信息的固有遗忘对于记忆的获取和巩固同样重要。最近的研究表明，Rac1 活性在固有遗忘中起着关键作用，以受控的方式维持大脑记忆管理系统的平衡。此外，Rac1 依赖性固有遗忘功能障碍可能导致神经和神经退行性疾病中的记忆缺陷。这里，这些新发现将为记忆和遗忘的神经生物学、病理机制以及改变固有遗忘机制的大脑疾病的潜在治疗方法提供新的思路。
