Early Tube Feeding Improves Nutritional Outcomes in Children with Neurological Disabilities: A Retrospective Cohort Study.

Tube feeding is a life-saving treatment for children with neurological disabilities (ND), who often suffer from malnutrition and feeding disorders. Nonetheless, it is still not widely used. Our aim was to evaluate the outcomes of exclusive tube feeding in a cohort of ND children. All consecutive ND children who started tube feeding at our center within the last 5 years were included in this retrospective study. Weight-for-age, body mass index (BMI), mid-upper arm circumference (MUAC) Z-scores, and symptoms were collected at baseline (V0), 6 (V1), and 12 months (V2) after gastrostomy placement. Fifty children (62% males) were included. The ND-underlying disease was genetic ( = 29, 58%), hypoxic-ischemic encephalopathy ( = 17, 34%), or metabolic ( = 4, 8%). Indications for tube feeding were malnutrition ( = 35, 70%), recurrent respiratory infections ( = 11, 22%), or both ( = 4, 8%). Enteral formulae were polymeric ( = 29, 58%), semi-elemental ( = 17, 34%), hypercaloric ( = 3, 6%), or elemental ( = 1, 2%). Homemade blended feed was offered to three children (6%) in addition to the formula. Weight and BMI increased over the study period. Except for constipation, all symptoms (cough, vomiting, and diarrhea) improved at 6 and 12 months ( < 0.05). Non-serious complications ( = 8; track disruption, granuloma, and skin infection) were observed. Longer disease duration ( < 0.001) at the start of tube feeding was associated with the absence of normalization of nutritional status (BMI Z-score > 2 SD) at 12 months. Tube feeding with commercially available enteral formulae should be started as early as possible for better outcomes.