Bar-Meir S, Bar-Tal L, Papa M Z, Peled Y
Isr J Med Sci. 1986 May;22(5):376-9.
Bromsulfophthalein (BSP) clearance and aminopyrine breath tests were performed in 13 patients with Gilbert's syndrome (GS) and six healthy volunteers. The BSP clearance was significantly lower in the GS patients (1.28 +/- 0.37 dl/min) than in the healthy volunteers (1.98 +/- 0.45 dl/min). The difference in clearance was not due to a significant difference in volume of distribution. The 13 patients with Gilbert's syndrome could be divided into three groups according to their BSP disappearance curves: in 7 the curves were normal; another 3 patients the disappearance rate of BSP was normal at the beginning, but became abnormally low later on; and in the last 3 patients, an abnormal BSP disappearance rate was observed during the whole experiment. Kinetic analysis of these BSP disappearance curves indicated increased regurgitation of BSP from the liver to the blood in the second group and defective hepatic BSP uptake in the third group. The aminopyrine breath test also demonstrated heterogeneity among the GS patients. There was no correlation between the impaired BSP clearance and the aminopyrine breath test.
对13例吉尔伯特综合征（GS）患者和6名健康志愿者进行了磺溴酞钠（BSP）清除试验和氨基比林呼吸试验。GS患者的BSP清除率（1.28±0.37 dl/min）显著低于健康志愿者（1.98±0.45 dl/min）。清除率的差异并非由于分布容积的显著差异所致。13例吉尔伯特综合征患者根据其BSP消失曲线可分为三组：7例曲线正常；另外3例患者BSP消失率起初正常，但随后变得异常低；最后3例患者在整个实验过程中观察到BSP消失率异常。对这些BSP消失曲线的动力学分析表明，第二组中BSP从肝脏反流至血液增加，第三组中肝脏对BSP的摄取存在缺陷。氨基比林呼吸试验也显示GS患者之间存在异质性。BSP清除受损与氨基比林呼吸试验之间无相关性。
