Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Health Psychology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Med Chem. 2024;31(34):5567-5575. doi: 10.2174/0929867331666230713143322.
Bipolar disorder (BD) is a severe mood disorder with uncertain causes and debilitating signs and symptoms. Gene expression is crucial to the pathophysiology of BD and could be influenced by genetic or epigenetic factors, by either direct modification of mRNA templates or by regulation of post-transcriptional translation. Recent evidence has shown that several critical processes in psychiatric diseases, such as neuronal activity or plasticity, synaptic transmission, and neuronal depolarization, have all been linked to circular RNAs (circRNAs). The circRNA profile of neuronal cells, which may be easily ascertained by a liquid biopsy, may shed light on the molecular pathophysiology of psychiatric disorders, including BD. This approach could aid in future development in diagnosis and treatment. In this review, we provide an in-depth understanding of the roles of circRNAs in the pathophysiology of BD and offer new insight into their potential as emerging diagnostic tools and therapeutic targets.
双相情感障碍（BD）是一种严重的情绪障碍，其病因不确定，症状和体征使人虚弱。基因表达对 BD 的病理生理学至关重要，可能受到遗传或表观遗传因素的影响，这些因素可以直接修饰 mRNA 模板，也可以通过调节转录后翻译来实现。最近的证据表明，几种关键过程在精神疾病中，如神经元活动或可塑性、突触传递和神经元去极化，都与环状 RNA（circRNA）有关。神经元细胞的 circRNA 谱可以通过液体活检轻松确定，这可能揭示精神疾病的分子病理生理学，包括 BD。这种方法可能有助于未来在诊断和治疗方面的发展。在这篇综述中，我们深入了解了 circRNAs 在 BD 病理生理学中的作用，并为它们作为新兴诊断工具和治疗靶点的潜在应用提供了新的见解。
