Wibowo Valent, Munshi Bijit, Ziolkowski Jessica, Wilson Ian, Ma Robert, Jansen Shirley
Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Department of Rehabilitation and Aged Care, Osborne Park Hospital, Perth, WA, Australia.
EJVES Vasc Forum. 2023 May 31;60:14-18. doi: 10.1016/j.ejvsvf.2023.05.012. eCollection 2023.
Functional near infrared spectroscopy (fNIRS) can be used to quantify stump oxygen saturation (SaO) as one of many possible causes of pain following major amputation. Although commonly used for cerebral perfusion monitoring during carotid or cardiac surgery, it can also be used to monitor tissue perfusion in the lower limb and predict healing following below knee amputation (BKA). The aim of this study was to measure the SaO trend as there is no validated oxygen threshold to diagnose insufficient flow into the arterial collateral network currently.
NIRS was used to measure SaO while performing treadmill exercise. Two BKA patients with chronic stump pain were asked to perform treadmill exercise while using their prosthesis and NIRS optode applied to the posterior stump to monitor SaO. Cases 1 and 2 showed a decline in SaO of 25% and 18%, respectively, while walking on the prosthesis. After superficial femoral artery (SFA) recanalisation and stenting, Case 1 showed improvement by maintaining SaO between 54% and 60% throughout treadmill exercise. In Case 2, perfusion could not be further improved, and the patient underwent through knee amputation.
fNIRS detected compressive ischaemia and exercise induced ischaemia as mechanisms of stump pain. Findings provided the multidisciplinary team with objective information, aiding decision making to treat stump pain.
功能近红外光谱技术(fNIRS)可用于量化残端血氧饱和度(SaO),这是大截肢术后疼痛的众多可能原因之一。尽管该技术通常用于颈动脉或心脏手术期间的脑灌注监测,但它也可用于监测下肢组织灌注,并预测膝下截肢(BKA)后的愈合情况。本研究的目的是测量SaO趋势,因为目前尚无经过验证的氧阈值来诊断动脉侧支网络血流不足。
在进行跑步机运动时,使用近红外光谱技术测量SaO。两名患有慢性残端疼痛的BKA患者在使用假肢且将NIRS光极应用于残端后部以监测SaO的情况下,被要求进行跑步机运动。病例1和病例2在使用假肢行走时,SaO分别下降了25%和18%。在股浅动脉(SFA)再通和支架置入术后,病例1在整个跑步机运动过程中通过将SaO维持在54%至60%之间而有所改善。在病例2中,灌注无法进一步改善,该患者接受了膝关节离断术。
fNIRS检测到压迫性缺血和运动诱导性缺血是残端疼痛的机制。研究结果为多学科团队提供了客观信息,有助于做出治疗残端疼痛的决策。