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在开放性四肢伤口情况下使用异种真皮基质:何时何地应予以考虑?

The use of xenogenic dermal matrices in the context of open extremity wounds: where and when to consider?

作者信息

Chintalapudi Nainisha, Rice Olivia M, Hsu Joseph R

机构信息

Atrium Health Musculoskeletal Institute, Charlotte, NC.

出版信息

OTA Int. 2023 Jul 11;6(4 Suppl):e237. doi: 10.1097/OI9.0000000000000237. eCollection 2023 Jul.

DOI:10.1097/OI9.0000000000000237
PMID:37448569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10337846/
Abstract

Optimal treatment of orthopaedic extremity trauma includes meticulous care of both bony and soft tissue injuries. Historically, clinical scenarios involving soft tissue defects necessitated the assistance of a plastic surgeon. While their expertise in coverage options and microvascular repair is invaluable, barriers preventing collaboration are common. Acellular dermal matrices represent a promising and versatile tool for orthopaedic trauma surgeons to keep in their toolbox. These biological scaffolds are each unique in how they are used and promote healing. This review explores some commercial products and offers guidance for selection in different clinical scenarios involving traumatic wounds.

摘要

骨科肢体创伤的最佳治疗包括对骨损伤和软组织损伤的精心护理。从历史上看,涉及软组织缺损的临床情况需要整形外科医生的协助。虽然他们在覆盖选择和微血管修复方面的专业知识非常宝贵,但阻碍合作的障碍却很常见。脱细胞真皮基质是骨科创伤外科医生值得拥有的一种有前景且用途广泛的工具。这些生物支架在使用方式和促进愈合方面各有独特之处。本综述探讨了一些商业产品,并为涉及创伤性伤口的不同临床场景中的选择提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/bdce29504ee8/oi9-6-e237-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/9d646d91f92a/oi9-6-e237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/b330899fe142/oi9-6-e237-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/bdce29504ee8/oi9-6-e237-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/9d646d91f92a/oi9-6-e237-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/b330899fe142/oi9-6-e237-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e8/10337846/bdce29504ee8/oi9-6-e237-g003.jpg

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本文引用的文献

1
Surgical Strategies: Necrotizing Fasciitis of the Foot and Ankle Treated With Dermal Regeneration Matrix for Limb Salvage.手术策略:应用皮肤再生基质进行保肢治疗的足部和踝关节坏死性筋膜炎。
Foot Ankle Int. 2021 Jan;42(1):107-114. doi: 10.1177/1071100720952087. Epub 2020 Sep 25.
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Bioengineered Skin Substitutes: the Role of Extracellular Matrix and Vascularization in the Healing of Deep Wounds.生物工程皮肤替代物:细胞外基质和血管生成在深度伤口愈合中的作用
J Clin Med. 2019 Dec 1;8(12):2083. doi: 10.3390/jcm8122083.
3
Understanding the role of mesenchymal stem cells in urinary bladder regeneration-a preclinical study on a porcine model.
了解间充质干细胞在膀胱再生中的作用——一种基于猪模型的临床前研究。
Stem Cell Res Ther. 2018 Nov 28;9(1):328. doi: 10.1186/s13287-018-1070-3.
4
Use of Hyaluronic Acid-Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series.基于透明质酸的生物双分子层基质在伤口床准备中的应用:病例系列
Eplasty. 2018 Feb 22;18:e10. eCollection 2018.
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Extracellular Matrix Applications in the Treatment of Open Fractures With Complex Wounds and Large Soft Tissue Defects.细胞外基质在治疗伴有复杂伤口和大面积软组织缺损的开放性骨折中的应用
J Orthop Trauma. 2018 Feb;32(2):e76-e80. doi: 10.1097/BOT.0000000000001034.
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Wounds. 2016 Nov;28(11):387-394.
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Management of Open Distal Lower Extremity Wounds With Exposed Tendons Using Porcine Urinary Bladder Matrix.使用猪膀胱基质治疗伴有肌腱外露的开放性下肢远端伤口
Wounds. 2016 Sep;28(9):306-316.
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Plast Reconstr Surg. 2015 Sep;136(3):603-609. doi: 10.1097/PRS.0000000000001521.
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