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多发性硬化症动物模型中的髓鞘再生:寻找难以捉摸的再生圣杯。

Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration.

作者信息

Packer Davin, Fresenko Emily E, Harrington Em P

机构信息

Department of Neurology, The Ohio State University College of Medicine, Columbus, OH, United States.

出版信息

Front Mol Neurosci. 2023 Jun 28;16:1207007. doi: 10.3389/fnmol.2023.1207007. eCollection 2023.

Abstract

Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in MS clinical trials. Animal models used to investigate oligodendroglial responses and regeneration of myelin vary considerably in the mechanism of demyelination, involvement of inflammatory cells, neurodegeneration and capacity for remyelination. The investigation of remyelination in the context of aging and an inflammatory environment are of considerable interest for the potential translation to progressive multiple sclerosis. Here we review how remyelination is assessed in mouse models of demyelination, differences and advantages of these models, therapeutic strategies that have emerged and current pro-remyelination clinical trials.

摘要

在过去十年中,髓鞘再生生物学以及恢复髓鞘以预防多发性硬化症(MS)中的神经退行性变和残疾的治疗潜力取得了显著进展,许多再生策略正在MS临床试验中进行测试。用于研究少突胶质细胞反应和髓鞘再生的动物模型在脱髓鞘机制、炎症细胞参与情况、神经退行性变和髓鞘再生能力方面差异很大。在衰老和炎症环境背景下对髓鞘再生的研究对于向进展性多发性硬化症的潜在转化具有相当大的意义。在这里,我们综述了在脱髓鞘小鼠模型中如何评估髓鞘再生、这些模型的差异和优势、已出现的治疗策略以及当前促进髓鞘再生的临床试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be2a/10338073/560ed7dc2e45/fnmol-16-1207007-g001.jpg

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