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MHC Ⅰ类和 MHC Ⅱ类报告小鼠可用于分析多发性硬化症小鼠模型中的免疫性少突胶质细胞。

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis.

机构信息

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.

出版信息

Elife. 2023 Apr 14;12:e82938. doi: 10.7554/eLife.82938.

DOI:10.7554/eLife.82938
PMID:37057892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10181822/
Abstract

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.

摘要

少突胶质细胞及其前体细胞在炎症反应中上调 MHC 途径，但这种表型变化的频率尚不清楚，这些免疫性少突胶质细胞的特征也尚未明确界定。我们生成了 MHC 类 I 和 II 转基因报告小鼠，以确定它们在炎症性脱髓鞘中的反应动态，这为在活体小鼠中监测多种细胞类型的 MHC 激活以及确定它们在衰老、损伤和疾病中的作用提供了一种手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2714/10181822/3fa1031d495e/elife-82938-fig11-figsupp1.jpg
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