Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, China.
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2235095. doi: 10.1080/14756366.2023.2235095.
The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.
Mannich 反应常用于向化合物分子中引入 N 原子，因此在药物合成中得到广泛应用。Mannich 反应在天然产物的结构修饰中占有一定比例。Mannich 碱的引入可以显著提高化合物的活性、亲水性和药用性质；因此，Mannich 反应被广泛用于天然产物的结构修饰。本文综述了 Mannich 反应在天然产物结构修饰中的应用，为天然产物的结构修饰提供了一种方法。
