印度糖尿病患者胰腺外分泌功能不全的患病率。

Prevalence of Pancreatic Exocrine Insufficiency among Patients with Diabetes Mellitus in India.

机构信息

MBBS, MD, DM (Endocrinology), Joshi Clinic and Department of Diabetology and Endocrinology, Lilavati Hospital, Mumbai, Maharashtra; Corresponding Author.

MBBS, DTM, DM (Endocrinology), MRCP (UK), Department of Endocrinology, Calcutta Medical Centre, Kolkata, West Bengal.

出版信息

J Assoc Physicians India. 2023 Jul;71(7):45-51. doi: 10.59556/japi.71.0316.

DOI:10.59556/japi.71.0316

PMID:37449690

Abstract

AIMS

We aimed to assess the prevalence of pancreatic exocrine insufficiency (PEI) in Indian patients with type 1 diabetes (T1D) or type 2 diabetes (T2D) using a unique diagnostic criterion.

METHODS

This multicenter study included patients aged ≥18 years with diabetes for at least 5 years. The sociodemographic characteristics, lifestyle habits, and clinical characteristics of patients were assessed. Patients were administered the PEI questionnaire (PEI-Q), and fecal elastase-1 (FE) concentration was measured. Patients were diagnosed to have PEI if they satisfied any two of the following three criteria: (a) a PEI-Q total symptom score of ≥0.60; (b) presence of malnutrition using the European Society of Clinical Nutrition and Metabolism diagnostic criteria for malnutrition; or (c) FE concentration <100 μg/gm stool.

RESULTS

CONCLUSIONS

Pancreatic exocrine insufficiency (PEI) was found to be prevalent in nearly one-fourth of Indian patients with diabetes, using composite diagnostic criteria.

摘要

目的

我们旨在使用独特的诊断标准评估印度 1 型糖尿病（T1D）或 2 型糖尿病（T2D）患者胰腺外分泌不足（PEI）的患病率。

方法

这项多中心研究纳入了至少患有 5 年糖尿病的年龄≥18 岁的患者。评估了患者的社会人口统计学特征、生活方式习惯和临床特征。对患者进行了 PEI 问卷（PEI-Q）和粪便弹性蛋白酶-1（FE）浓度的检测。如果患者符合以下三个标准中的任意两个，则诊断为患有 PEI：（a）PEI-Q 总症状评分≥0.60；（b）存在欧洲临床营养和代谢学会营养不良诊断标准的营养不良；或（c）FE 浓度＜100μg/gm 粪便。