Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
J Nat Prod. 2023 Jul 28;86(7):1643-1653. doi: 10.1021/acs.jnatprod.2c00842. Epub 2023 Jul 14.
Twelve new fungal polyketides, koningiopisins I-P (-) and trichoketides C-F (-), together with six known congeners (-), were isolated from , a rhizosphere fungus obtained from the medicinal plant . Their structures and absolute configurations were established by spectroscopic analysis, single-crystal X-ray diffraction, the modified Mosher's method, chemical derivatization, the octant rule, and C NMR and ECD calculations. Compounds - are tricyclic polyketides possessing an octahydrochromene framework with a 6,8-dioxabicyclo[3.2.1]octane core. Compounds and contain a unique ketone carbonyl group at C-7 and differ from other members of this group of compounds with the ketone carbonyl group at C-1. Compounds , , and showed inhibitory activity on LPS-induced BV-2 cells on NO production with IC values of 14 ± 1, 3.0 ± 0.5, and 8.9 ± 2.7 μM, respectively.
从药用植物的根际真菌中分离得到一种新的真菌聚酮化合物，命名为koningiopisins I-P（-）和trichoketides C-F（-），以及 6 种已知的同系物（-）。通过光谱分析、单晶 X 射线衍射、改进的 Mosher 法、化学衍生化、八角规则以及 13C NMR 和 ECD 计算确定了它们的结构和绝对构型。化合物-是具有八氢色烯骨架和 6,8-二氧杂双环[3.2.1]辛烷核心的三环聚酮化合物。化合物和含有独特的酮羰基在 C-7 位，与该组化合物中酮羰基在 C-1 位的其他成员不同。化合物、和对 LPS 诱导的 BV-2 细胞中 NO 生成表现出抑制活性，IC50 值分别为 14 ± 1、3.0 ± 0.5 和 8.9 ± 2.7 μM。
