阿尔茨海默病不同阶段的帕佩兹环的功能和结构连接。
Functional and structural connectivity in the Papez circuit in different stages of Alzheimer's disease.
机构信息
Graduate School of Health Sciences, Istanbul University, 34216 Istanbul, Turkey; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey.
Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey.
出版信息
Clin Neurophysiol. 2023 Sep;153:33-45. doi: 10.1016/j.clinph.2023.06.008. Epub 2023 Jun 30.
OBJECTIVE
Alzheimer's disease (AD) is a progressive neurodegenerative continuum with memory impairment. We aimed to examine the detailed functional (FC) and structural connectivity (SC) pattern of the Papez circuit, known as the memory circuit, along the AD.
METHODS
MRI data of 15 patients diagnosed with AD dementia (ADD), 15 patients with the amnestic mild cognitive impairment (MCI), and 15 patients with subjective cognitive impairment were analyzed. The FC analyses were performed between main nodes of the Papez circuit, and the SC was quantified as fractional anisotropy (FA) of the main white matter pathways of the Papez circuit.
RESULTS
The FC between the retrosplenial (RSC) and parahippocampal cortices (PHC) was the earliest affected FC, while a manifest SC change in the ventral cingulum and fornix was observed in the later ADD stage. The RSC-PHC FC and the ventral cingulum FA efficiently predicted the memory performance of the non-demented participants.
CONCLUSIONS
Our findings revealed the importance of the Papez circuit as target regions along the AD.
SIGNIFICANCE
The ventral cingulum connecting the RSC and PHC, a critical overlap area between the Papez circuit and the default mode network, seems to be a target region associated with the earliest objective memory findings in AD.
目的
阿尔茨海默病（AD）是一种进行性神经退行性连续体，伴有记忆障碍。我们旨在研究被称为记忆回路的帕佩兹回路的详细功能（FC）和结构连接（SC）模式，沿着 AD 的轨迹。
方法
对 15 名被诊断为 AD 痴呆（ADD）的患者、15 名有遗忘性轻度认知障碍（MCI）的患者和 15 名有主观认知障碍的患者进行 MRI 数据分析。进行了 Papez 回路主要节点之间的 FC 分析，并将 Papez 回路的主要白质通路的分数各向异性（FA）量化为 SC。
结果
后扣带回（RSC）和海马旁回（PHC）之间的 FC 是最早受影响的 FC，而在晚期 ADD 阶段，腹侧扣带和穹窿出现明显的 SC 变化。RSC-PHC FC 和腹侧扣带 FA 有效地预测了非痴呆参与者的记忆表现。
结论
我们的发现揭示了帕佩兹回路作为 AD 沿线目标区域的重要性。
意义
连接 RSC 和 PHC 的腹侧扣带，是帕佩兹回路和默认模式网络之间的关键重叠区域，似乎是与 AD 中最早的客观记忆发现相关的目标区域。
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