Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China.
Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing, China; Research Center of Psychology and Social Development, Southwest University, Chongqing, China.
Appetite. 2023 Sep 1;188:106763. doi: 10.1016/j.appet.2023.106763. Epub 2023 Jul 13.
Converging evidence points to the crucial role of brain connectivity involved in aberrant behavioral control and reward reactivity in the onset and maintenance of binge eating. However, the directional interaction pattern between brain's reward and inhibitory control systems in people with binge eating episodes is largely unknown.
Resting-state fMRI data were collected from 36 adults with binge eating episodes (age: 19.05 ± 0.90) and 36 well-matched controls (age: 18.88 ± 0.78). We applied spectral dynamic causal modeling approach to estimate effective connectivity of the executive control network (ECN) and reward network (RN) with 15 predefined regions of interest, and investigate the between-group differences in directional connectivity.
Compared with controls, the positive connections within the ECN were significantly strengthened in individuals with binge eating episodes, while the negative connections from the ECN to RN and from the RN to ECN were significantly weakened. In adults with binge eating episodes, the RN→ECN connectivity was positively related to binge frequency even controlling for age, sex, and body mass index.
This study represents an important first step in addressing the role of directional integration between reward and inhibitory control networks in binge eating, and provides novel evidence that the ability of people with binge eating episodes to maintain a balance between inhibitory control and reward reactivity is decreased, as reflected by diminished bidirectional negative effects of prefrontal-subcortical circuitry at rest.
越来越多的证据表明，大脑连接在异常行为控制和奖励反应中起着至关重要的作用，这与暴食的发生和维持有关。然而，暴食发作患者大脑奖励和抑制控制系统之间的定向相互作用模式在很大程度上尚不清楚。
从 36 名有暴食发作的成年人（年龄：19.05±0.90）和 36 名匹配良好的对照者（年龄：18.88±0.78）中采集静息态 fMRI 数据。我们应用谱动态因果建模方法来估计执行控制网络（ECN）和奖励网络（RN）与 15 个预先定义的感兴趣区域的有效连接，并研究组间定向连接的差异。
与对照组相比，暴食发作个体的 ECN 内正连接显著增强，而 ECN 到 RN 和 RN 到 ECN 的负连接显著减弱。在暴食发作的成年人中，即使控制年龄、性别和体重指数，RN→ECN 连接与暴食频率呈正相关。
这项研究代表了在解决奖励和抑制控制网络之间的定向整合在暴食中的作用方面的重要的第一步，并且提供了新的证据，表明暴食发作者维持抑制控制和奖励反应之间平衡的能力降低，这反映在休息时前额叶-皮质下回路的双向负效应减弱。
