University of Oxford, United Kingdom; Chang Gung Memorial Hospital, Keelung, Taiwan, and Chang Gung University, Taiwan.
University of Oxford, United Kingdom.
J Am Acad Child Adolesc Psychiatry. 2024 Apr;63(4):407-421. doi: 10.1016/j.jaac.2023.06.022. Epub 2023 Jul 13.
To examine the risk of anxiety disorders in offspring of parents with mood disorders.
We conducted a systematic review and meta-analysis. We searched 4 electronic databases (Medline, Embase, PsycINFO, and Web of Science [core collection]) to identify cross-sectional and cohort studies that examined the association between parental mood disorders (including bipolar disorder and unipolar depression) and risk of anxiety disorders in offspring. Pooled risk ratios (RRs) of overall and specific anxiety disorders were synthesized using a random effects model. Subgroup analyses and meta-regression were performed to identify moderation factors.
A total of 35 studies were included in the final analysis. Our results showed higher risks of all types of anxiety disorders in the offspring of parents with mood disorders (any anxiety disorder, RR = 1.82, 95% CI = 1.47-2.26), except for agoraphobia (RR = 1.08, 95% CI = 0.56-2.08), and with an especially elevated risk of panic disorder (RR = 3.07, 95% CI = 2.19-4.32). Subgroup analysis demonstrated no significant difference between the risks of anxiety disorders across the offspring of parents with bipolar disorder as opposed to unipolar depression. The absence of anxiety disorders in control parents, younger offspring age, and specific parent/offspring sex were associated with higher RRs for some anxiety disorders in offspring of parents with mood disorders.
Our findings suggest a robust relationship between parental mood disorders and offspring anxiety disorders, and highlight the potential value of prevention and early intervention for anxiety disorders in this context.
DIVERSITY & INCLUSION STATEMENT: We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list.
Anxiety Disorders in Offspring of Parents with Mood Disorders: A Systematic Review; https://www.crd.york.ac.uk/prospero/; CRD42021215058.
探讨父母患有心境障碍对后代焦虑障碍发病风险的影响。
我们进行了系统评价和荟萃分析。我们检索了 4 个电子数据库（Medline、Embase、PsycINFO 和 Web of Science [核心合集]），以确定考察父母心境障碍（包括双相障碍和单相抑郁）与后代发生焦虑障碍之间相关性的横断面研究和队列研究。使用随机效应模型综合整体和特定焦虑障碍的汇总风险比（RR）。进行亚组分析和元回归以确定调节因素。
共有 35 项研究纳入最终分析。结果显示，与父母心境障碍无关的子代发生各种焦虑障碍的风险更高（任何焦虑障碍，RR=1.82，95%CI=1.47-2.26），除了广场恐惧症（RR=1.08，95%CI=0.56-2.08），惊恐障碍的风险尤其升高（RR=3.07，95%CI=2.19-4.32）。亚组分析表明，父母为双相障碍与单相抑郁的子代发生焦虑障碍的风险之间无显著差异。控制父母无焦虑障碍、子代年龄较小和特定父母-子女性别与心境障碍父母的子代发生某些焦虑障碍的 RR 较高相关。
本研究结果提示父母心境障碍与后代焦虑障碍之间存在显著关联，强调在这种情况下针对焦虑障碍进行预防和早期干预的潜在价值。
我们致力于确保招募人类参与者时存在种族、民族和/或其他类型的多样性。本文的一位或多位作者自认为是科学领域中一个或多个历史上代表性不足的种族和/或族裔群体的成员。在引用与本工作相关的科学文献的同时，我们还积极努力在参考文献中纳入历史上代表性不足的种族和/或族裔群体。
父母患有心境障碍对后代焦虑障碍发病风险的影响：系统评价；https://www.crd.york.ac.uk/prospero/；CRD42021215058。
