Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, CRC, Rm B2-3561, Bethesda, MD, 20892, USA.
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
BMC Med Genomics. 2023 Jul 15;16(1):168. doi: 10.1186/s12920-023-01593-w.
Cancer researchers often seek user-friendly interactive tools for validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples. To aid researchers working on the both low- and high-grade gliomas, we developed Glioma-BioDP, a web tool for exploration and visualization of RNA and protein expression profiles of interest in these tumor types. Glioma-BioDP is user friendly application that include expression data from both the low- and high-grade glioma patient samples from The Cancer Genome Atlas and enabled querying by mRNA, microRNA, and protein level expression data from Illumina HiSeq and RPPA platforms respectively. Glioma-BioDP provides advance query interface and enables users to explore the association of genes, proteins, and miRNA expression with molecular and/or histological subtypes of gliomas, surgical resection status and survival. The prognostic significance and visualization of the selected expression profiles can be explored using interactive utilities provided. This tool may also enable validation and generation of new hypotheses of novel therapies impacting gliomas that aid in personalization of treatment for optimum outcomes.
癌症研究人员通常寻求用户友好的交互式工具，用于验证、探索、分析和可视化癌症患者样本中的分子谱。为了帮助从事低级别和高级别神经胶质瘤研究的研究人员，我们开发了 Glioma-BioDP，这是一种用于探索和可视化这些肿瘤类型中感兴趣的 RNA 和蛋白质表达谱的网络工具。Glioma-BioDP 是一个用户友好的应用程序，它包含了来自癌症基因组图谱的低级别和高级别神经胶质瘤患者样本的表达数据，并分别支持通过 mRNA、microRNA 和蛋白质水平的 Illumina HiSeq 和 RPPA 平台表达数据进行查询。Glioma-BioDP 提供了高级查询界面，使用户能够探索基因、蛋白质和 miRNA 表达与神经胶质瘤的分子和/或组织学亚型、手术切除状态和生存之间的关联。使用提供的交互式实用程序可以探索选定表达谱的预后意义和可视化。该工具还可以帮助验证和生成影响神经胶质瘤的新治疗方法的新假设，从而实现最佳治疗效果的治疗个性化。
