NFAT 信号转导在癌症中的失调：在癌症干细胞中的新作用。
NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells.
机构信息
Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110001, China.
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110001, China.
出版信息
Biomed Pharmacother. 2023 Sep;165:115167. doi: 10.1016/j.biopha.2023.115167. Epub 2023 Jul 14.
The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional regulator of activated T cells. The NFAT family is involved in the development of tumors. Furthermore, recent evidence reveals that NFAT proteins regulate the development of inflammatory and immune responses. New discoveries have also been made about the mechanisms by which NFAT regulates cancer progression through cancer stem cells (CSC). Here, we discuss the role of the NFAT family in the immune system and various cancer types.
核因子活化 T 细胞（NFAT）最初被鉴定为活化 T 细胞的转录调节剂。NFAT 家族参与肿瘤的发生。此外，最近的证据表明 NFAT 蛋白调节炎症和免疫反应的发展。通过癌症干细胞（CSC），NFAT 调节癌症进展的机制也有了新的发现。在这里，我们讨论了 NFAT 家族在免疫系统和各种癌症类型中的作用。
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