在射血分数降低的心力衰竭中，CA125、半乳糖凝集素-3和FGF-23相互关联。
CA125, Galectin-3 and FGF-23 are interrelated in heart failure with reduced ejection fraction.
作者信息
Gruson Damien, Maisin Diane, Pouleur Anne-Catherine, Ann Sylvie A, Rousseau Michel F
机构信息
Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium.
Department of Clinical Biochemistry, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium.
出版信息
EJIFCC. 2023 Jul 10;34(2):103-109. eCollection 2023 Jul.
BACKGROUND
Carbohydrate Antigen 125 (CA125) is the most widely used biomarker in ovarian cancer screening. In patients with heart failure (HF), increased levels of CA125 have been observed and related to disease severity. Our objective was to determine the association of CA125 levels with two biomarkers of adverse remodeling in HF patients with reduced ejection fraction (HFrEF).
METHODS
CA125 circulating levels were determined with an electrochemiluminscent immunoassay. Concentrations of B-type natriuretic peptide (BNP), N-terminal proBNP (Nt-proBNP), Galectin-3 and Fibroblast Growth Factor 23 (FGF23) were also measured by immunoassays.
RESULTS
CA125 levels were increased in HFrEF, were associated to disease severity according NYHA classes. Median CA125 concentration was also significantly related to cardiovascular mortality. CA125 concentrations were positively and significantly associated to Galectin-3 and FGF23.
CONCLUSIONS
Concentrations of CA125 are increased in patients with HFrEF, associated to disease severity and adverse cardiovascular outcomes. CA125 levels are also correlated to Galectin-3 and FGF-23, two biomarkers related to fibrosis and cardiovascular remodeling.
背景
糖类抗原125（CA125）是卵巢癌筛查中使用最广泛的生物标志物。在心力衰竭（HF）患者中，已观察到CA125水平升高，且与疾病严重程度相关。我们的目的是确定射血分数降低的心力衰竭（HFrEF）患者中CA125水平与两种不良重塑生物标志物之间的关联。
方法
采用电化学发光免疫分析法测定循环中CA125水平。还通过免疫分析法测量了B型利钠肽（BNP）、N末端proBNP（Nt-proBNP）、半乳糖凝集素-3和成纤维细胞生长因子23（FGF23）的浓度。
结果
HFrEF患者的CA125水平升高，根据纽约心脏协会（NYHA）分级与疾病严重程度相关。CA125浓度中位数也与心血管死亡率显著相关。CA125浓度与半乳糖凝集素-3和FGF23呈正相关且显著相关。
结论
HFrEF患者的CA125浓度升高，与疾病严重程度和不良心血管结局相关。CA125水平还与半乳糖凝集素-3和FGF-23相关，这两种生物标志物与纤维化和心血管重塑有关。
Zotero 插件