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病毒性疾病后斜视性眼阵挛-肌阵挛-共济失调综合征1例罕见病例

A Rare Case of Opsoclonus Myoclonus Ataxia Syndrome Post Viral Illness.

作者信息

Shah Nauka S, Pathak Jaya, Shah Purva C, Bharmal Ummayhany F, Ansari Maliha I

机构信息

Department of Medicine, Baroda Medical College, Maharaja Sayajirao (MS) University, Vadodara, IND.

Department of Internal Medicine, Baroda Medical College, Maharaja Sayajirao (MS) University, Vadodara, IND.

出版信息

Cureus. 2023 Jun 14;15(6):e40396. doi: 10.7759/cureus.40396. eCollection 2023 Jun.

Abstract

Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare inflammatory neurological disorder characterized by ocular, motor, behavioral, language, and sleep disturbances. It usually affects infants and young children but may affect adults. A 28-year-old male was brought to our emergency ward with complaints of involuntary spontaneous eye movements and jerky movements of limbs with imbalance while walking. He had a history of short febrile illness 10 days prior. His magnetic resonance imaging (MRI) of the brain, cerebrospinal fluid (CSF) analysis, and other routine investigations were normal. The patient was treated with injectable methylprednisolone (1 g) given for five days along with other supportive therapy. A significant reduction in the opsoclonus, myoclonus, and ataxia was seen on a six-month follow-up. OMAS should be identified early to avoid the use of inappropriate medications, and immunotherapy must be provided as early as possible in order to prevent irreversible neurological damage.

摘要

眼阵挛-肌阵挛-共济失调综合征(OMAS)是一种罕见的炎症性神经系统疾病,其特征为眼部、运动、行为、语言和睡眠障碍。它通常影响婴幼儿,但也可能影响成年人。一名28岁男性因非自愿性自发眼球运动、四肢抽搐性运动且行走时失衡而被送至我们的急诊病房。他在10天前有过短期发热病史。他的脑部磁共振成像(MRI)、脑脊液(CSF)分析及其他常规检查均正常。该患者接受了为期五天的静脉注射甲泼尼龙(1g)治疗以及其他支持性治疗。在六个月的随访中,眼阵挛、肌阵挛和共济失调有显著减轻。应尽早识别OMAS以避免使用不恰当的药物,并且必须尽早提供免疫治疗以防止不可逆的神经损伤。

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