Wang Tiannan, Zhang Huina, Liu Yang, Zhao Chengquan
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
J Clin Transl Pathol. 2023 Jun;3(2):75-83. doi: 10.14218/jctp.2023.00004. Epub 2023 Apr 21.
Over the past decades, cervical cancer has been a worldwide public health problem. Population-based early cancer risk detection and prevention approaches, including vaccination, cytology screening and human papilloma virus (HPV) detection, with the aligned clinical management, have formed a well-rounded high-quality implementation system for cervical cancer control, and revolutionarily improved the quality of life of women: (1) the success of cervical cancer screening practices, (2) standardization of The Bethesda system for reporting cervicovaginal cytology, (3) improvement in the understanding of HPV pathogenesis in cervical cancer, and (4) the development of appropriate management approaches have significantly decreased the disease burden of cervical cancer worldwide. This scoping review aimed to understand the evolvement of cervical cancer screening and management guidelines, describe the Bethesda cervical cytology reporting system, and HPV vaccines and tests, and highlight the key information of present policies and practices.
在过去几十年里，宫颈癌一直是一个全球性的公共卫生问题。基于人群的早期癌症风险检测和预防方法，包括疫苗接种、细胞学筛查和人乳头瘤病毒（HPV）检测，以及相应的临床管理，已经形成了一个全面的高质量宫颈癌防控实施体系，并彻底改善了女性的生活质量：（1）宫颈癌筛查实践的成功；（2）阴道镜细胞学报告的贝塞斯达系统的标准化；（3）对宫颈癌中HPV发病机制认识的提高；（4）适当管理方法的发展显著降低了全球宫颈癌的疾病负担。本综述旨在了解宫颈癌筛查和管理指南的演变，描述贝塞斯达宫颈细胞学报告系统、HPV疫苗和检测，并强调当前政策和实践的关键信息。
