克罗恩病排除饮食联合部分肠内营养在妊娠期克罗恩病治疗中的新应用。

Ukovic Bianca, Chapman Brooke, Schulberg Julien, De Cruz Peter, Choy Matthew C

Nutrition and Dietetics Department, Division of Allied Health, Austin Health, Heidelberg, Australia.

Department of Gastroenterology, Austin Health, Heidelberg, Australia.

ACG Case Rep J. 2023 Jul 13;10(7):e01078. doi: 10.14309/crj.0000000000001078. eCollection 2023 Jul.

The Crohn's Disease Exclusion Diet (CDED) with partial enteral nutrition (PEN) is an emerging treatment option for Crohn's disease (CD). A 35-year-old pregnant woman presented with newly diagnosed ileal CD. At 14/40 gestation, CDED + PEN was prescribed without drug therapy. Outcomes included Harvey-Bradshaw Index, weight, and bowel wall thickness/Limberg score measured on intestinal ultrasound (IUS). In this patient, CDED + PEN achieved clinical and biochemical remission, improvements on IUS, gestational weight gain, and healthy birth weight without drug therapy. Sustained remission was achieved postpartum. Our case highlights the potential effectiveness of CDED + PEN to induce remission for active CD during pregnancy.

克罗恩病排除饮食（CDED）联合部分肠内营养（PEN）是克罗恩病（CD）一种新出现的治疗选择。一名35岁孕妇被诊断为新发回肠型CD。妊娠14周时，在未进行药物治疗的情况下，给予CDED + PEN治疗。观察指标包括哈维-布拉德肖指数、体重以及通过肠道超声（IUS）测量的肠壁厚度/林伯格评分。在该患者中，CDED + PEN在未进行药物治疗的情况下实现了临床和生化缓解，IUS检查结果改善，孕期体重增加，且出生体重正常。产后实现了持续缓解。我们的病例突出了CDED + PEN诱导孕期活动性CD缓解的潜在有效性。