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泛癌症分析表明，IBSP 是包括骨肉瘤在内的多种癌症类型的潜在预后和免疫治疗生物标志物。

Pan-cancer analysis shows that IBSP is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including osteosarcoma.

机构信息

Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

出版信息

Front Immunol. 2023 Jun 29;14:1188256. doi: 10.3389/fimmu.2023.1188256. eCollection 2023.

DOI:10.3389/fimmu.2023.1188256
PMID:37457709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10339805/
Abstract

BACKGROUND

IBSP is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that plays a vital role in bone formation, renewal and repair. Emerging evidence revealed that IBSP participated in the tumorigenesis and progression in some cancers. However, its significance in tumour prognosis and immunotherapy is still unknown.

METHODS

In the current study, we studied the role of IBSP in tumorigenesis, tumor diagnosis, genomic heterogeneity, methylation modifications, immune infiltration, and therapy response in pan-cancer. In addition, we constructed a risk score model to assessed the prognostic classification efficiency of IBSP using the co-expression genes of IBSP in osteosarcoma (OS), and analyzed the expression and role of IBSP in OS through a series of assays .

RESULTS

IBSP was upregulated in various cancers compared to the paired normal tissues, and it was strongly correlated with the prognosis, pathological stage, diagnostic accuracy, genomic heterogeneity, methylation modification, immune infiltration, immune and checkpoint. Moreover, the predictive model we established in combination with the clinical characteristics of OS patients showed high survival predictive power in these individuals. The assays in vitro showed that IBSP promoted the proliferation, migration and invasion of OS cells, which further confirmed IBSP's role in cancers.

CONCLUSIONS

Our research revealed the multifunctionality of IBSP in the tumorigenesis, progression and therapy in various cancers, which demonstrated that IBSP may serve as a potential prognostic biomarker and a novel immunotherapy target in pan-cancer.

摘要

背景

IBSP 是小整合素结合配体 N-连接糖蛋白（SIBLING）家族的成员，在骨形成、更新和修复中发挥着重要作用。新出现的证据表明，IBSP 参与了一些癌症的肿瘤发生和进展。然而，其在肿瘤预后和免疫治疗中的意义尚不清楚。

方法

在本研究中，我们研究了 IBSP 在泛癌中的肿瘤发生、肿瘤诊断、基因组异质性、甲基化修饰、免疫浸润和治疗反应中的作用。此外，我们构建了一个风险评分模型，使用骨肉瘤（OS）中 IBSP 的共表达基因评估 IBSP 的预后分类效率，并通过一系列实验分析 IBSP 在 OS 中的表达和作用。

结果

与配对的正常组织相比，IBSP 在各种癌症中上调，并且与预后、病理分期、诊断准确性、基因组异质性、甲基化修饰、免疫浸润和免疫检查点密切相关。此外，我们结合 OS 患者的临床特征建立的预测模型在这些个体中表现出较高的生存预测能力。体外实验表明，IBSP 促进了 OS 细胞的增殖、迁移和侵袭，进一步证实了 IBSP 在癌症中的作用。

结论

我们的研究揭示了 IBSP 在各种癌症中的肿瘤发生、进展和治疗中的多功能性，表明 IBSP 可能成为泛癌中的一种潜在预后生物标志物和新型免疫治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/0b363b5cad1c/fimmu-14-1188256-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/7ba720174b10/fimmu-14-1188256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/d1a45850e683/fimmu-14-1188256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/30ea72016884/fimmu-14-1188256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/3dc115dc95cc/fimmu-14-1188256-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/0c34206fc156/fimmu-14-1188256-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/8625e5adc0da/fimmu-14-1188256-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/1ea28eba7aa1/fimmu-14-1188256-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/898ae173bdaa/fimmu-14-1188256-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/80e25d58e9f4/fimmu-14-1188256-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/0b363b5cad1c/fimmu-14-1188256-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/7ba720174b10/fimmu-14-1188256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/d1a45850e683/fimmu-14-1188256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/30ea72016884/fimmu-14-1188256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/3dc115dc95cc/fimmu-14-1188256-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/0c34206fc156/fimmu-14-1188256-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/8625e5adc0da/fimmu-14-1188256-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/1ea28eba7aa1/fimmu-14-1188256-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/898ae173bdaa/fimmu-14-1188256-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/80e25d58e9f4/fimmu-14-1188256-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1fb/10339805/0b363b5cad1c/fimmu-14-1188256-g010.jpg

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