Recyclable Polymer Supported DMAP Catalyzed Cascade Synthesis of α-Pyrones.
作者信息
Jain Anshul, Kumari Akanksha, Saha Suman K, Shukla Khyati, Chauhan Ashwani, Metre Ramesh K, Rana Nirmal K
机构信息
Department of Chemistry, Indian Institute of Technology Jodhpur, Rajasthan-342030, India.
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India.
出版信息
J Org Chem. 2023 Aug 4;88(15):11346-11351. doi: 10.1021/acs.joc.3c01052. Epub 2023 Jul 17.
Polymer-supported catalysts have emerged as one of the sustainable and cost-effective alternatives in organic synthetic chemistry. We have developed the first polymer-supported DMAP catalyzed one-pot synthesis of diversely substituted α-pyrones. The cascade approach involves C5 conjugate addition of 5-oxazol-4-ones to α,β-unsaturated-β-ketoesters followed by lactonization/elimination.
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