Hematology-Oncology Department, Hotel Dieu De France Hospital, Saint Joseph University of Beirut, Riad El Solh, Lebanon.
Division of Hematology-Oncology, Internal Medicine Department, George Washington University Hospital, 20037, Washington DC, USA.
Pharmacogenomics. 2023 Jun;24(9):509-522. doi: 10.2217/pgs-2023-0027. Epub 2023 Jul 17.
Bladder cancer is a common urogenital malignancy characterized by frequent genetic alterations. Histone demethylase gene is commonly mutated in bladder cancer. To review the characteristics of and its mutation consequences, and to introduce a potential KDM6A-targeted treatment. We conducted a comprehensive literature search using two electronic databases, MEDLINE and Cochrane Library, to retrieve topic-related articles from July 2013 to July 2022 using keywords 'KDM6A', 'bladder cancer', 'UTX', 'treatment' and 'mutation'. Five reviewers independently screened literature search results and abstracted data from included studies. Descriptive analysis was conducted and 30 articles were retained. A total of 30 articles were retrieved. Experimental and clinical data were collected and grouped by theme. Therapeutic strategies are depicted and organized by tables for a better understanding. This review demonstrates that has crucial implications in bladder cancer pathogenesis and treatment.
膀胱癌是一种常见的泌尿生殖系统恶性肿瘤，其特征是经常发生遗传改变。组蛋白去甲基化酶基因在膀胱癌中经常发生突变。为了综述 和其突变后果的特征，并介绍一种潜在的 KDM6A 靶向治疗方法。我们使用两个电子数据库 MEDLINE 和 Cochrane Library 进行了全面的文献检索，使用关键字 'KDM6A'、'膀胱癌'、'UTX'、'治疗' 和 '突变' 从 2013 年 7 月到 2022 年 7 月检索到与主题相关的文章。五位审稿人独立筛选文献检索结果并从纳入的研究中提取数据。进行了描述性分析，保留了 30 篇文章。共检索到 30 篇文章。通过主题收集和分组实验和临床数据。为了更好地理解，治疗策略通过表格进行描述和组织。本综述表明 在膀胱癌的发病机制和治疗中具有重要意义。
