Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT.
J Immunol. 2023 Aug 1;211(3):333-342. doi: 10.4049/jimmunol.2300141.
One of the main goals in T cell biology has been to investigate how TCR recognition of peptide:MHC (pMHC) determines T cell phenotype and fate. Ag recognition is required to facilitate survival, expansion, and effector function of T cells. Historically, TCR affinity for pMHC has been used as a predictor for T cell fate and responsiveness, but there have now been several examples of nonfunctional high-affinity clones and low-affinity highly functional clones. Recently, more attention has been paid to the TCR being a mechanoreceptor where the key biophysical determinant is TCR bond lifetime under force. As outlined in this review, the fundamental parameters between the TCR and pMHC that control Ag recognition and T cell triggering are affinity, bond lifetime, and the amount of force at which the peak lifetime occurs.
T 细胞生物学的主要目标之一是研究 TCR 识别肽：MHC（pMHC）如何决定 T 细胞表型和命运。Ag 识别对于促进 T 细胞的存活、扩增和效应功能是必需的。从历史上看，TCR 对 pMHC 的亲和力一直被用作预测 T 细胞命运和反应性的指标，但现在已经有几个非功能性高亲和力克隆和低亲和力高功能克隆的例子。最近，人们越来越关注 TCR 作为机械感受器，其关键生物物理决定因素是 TCR 在力下的键寿命。正如本综述所述，控制 Ag 识别和 T 细胞触发的 TCR 与 pMHC 之间的基本参数是亲和力、键寿命和达到峰值寿命的力的大小。
