食指与无名指长度的比值，作为产前睾酮-雌激素平衡的潜在标志物，与胫骨后倾角有关吗？
Is the ratio of the index to ring finger length, a potential marker for prenatal testosterone-estrogen balance, related to posterior tibial slope?
机构信息
Konya City Hospital, Department of Orthopaedics & Traumatology, Konya, Turkey.
Necmettin Erbakan University School of Medicine, Department of Orthopaedics & Traumatology, Konya, Turkey.
出版信息
Knee. 2023 Aug;43:200-207. doi: 10.1016/j.knee.2023.07.001. Epub 2023 Jul 16.
BACKGROUND
The 2D:4D ratio, an indicator of prenatal testosterone-estrogen balance, is the index finger (second finger) size's ratio to the ring finger (fourth finger) size. Asymmetric growth in the proximal tibial growth plate is considered to cause the increased posterior tibial slope (PTS) formation. Factors determining the amount of this asymmetry still need clarification. This study aims to evaluate the relationship between the 2D:4D ratio, which indicates the prenatal testosterone-estrogen balance, and the PTS.
METHOD
Meeting the study criteria, 267 patients were included in the study. We measured the medial PTS (MPTS) and lateral PTS (LPTS) on MRI images and the lengths of the second and fourth fingers on both hands of the patients. Additionally, we compared 2D:4D ratios and MPTS and LPTS measurements.
RESULTS
We found a significant negative correlation between MPTS and the 2D:4D ratio, as well as between LPTS and the 2D:4D ratio in both hands (MPTS left vs. right hand: P < 0.001, r = -0.627 vs. P < 0.001, r = -0.498) (LPTS left vs. right hand: P < 0.001, r = 0.589 vs. P < 0.001, r = 0.404). Separately among males and females, there was a significant negative correlation between MPTS and the 2D:4D ratio, as well as between LPTS and the 2D:4D ratio in both hands (for males: MPTS left vs. right hand: P < 0.001, r = -0.607 vs. P < 0.001, r = -0.540)(for males: LPTS left vs.right hand: P < 0.001, r = 0.451 vs. P < 0.001, r = 0.406) (for females:MPTS left vs. right hand: P < 0.001, r = -0.638 vs. P < 0.001, r = -0.446) (for females:LPTS left vs.right hand: P < 0.001, r = 0.618 vs. P < 0.001, r = 0.403).
CONCLUSIONS
The 2D:4D ratio, an indicator of intrauterine testosterone-estrogen balance, is related to PTS. The effect of testosterone on the growth plate of the proximal tibia may be one of the factors determining the PTS value.
LEVEL OF EVIDENCE
III retrospective comparative study.
背景
2D:4D 比值，一种产前睾酮-雌激素平衡的指标，是食指（第二指）大小与环指（第四指）大小的比值。胫骨近端生长板的不对称生长被认为会导致后胫骨倾斜角（PTS）的形成。决定这种不对称程度的因素仍需阐明。本研究旨在评估 2D:4D 比值（指示产前睾酮-雌激素平衡）与 PTS 之间的关系。
方法
符合研究标准的 267 名患者被纳入研究。我们在 MRI 图像上测量了内侧 PTS（MPTS）和外侧 PTS（LPTS）以及患者双手的第二和第四指长度。此外，我们比较了 2D:4D 比值和 MPTS 和 LPTS 测量值。
结果
我们发现 MPTS 与 2D:4D 比值之间存在显著负相关，并且双手的 LPTS 与 2D:4D 比值之间也存在显著负相关（MPTS 左 vs. 右：P < 0.001，r = -0.627 vs. P < 0.001，r = -0.498）（LPTS 左 vs. 右：P < 0.001，r = 0.589 vs. P < 0.001，r = 0.404）。单独在男性和女性中，MPTS 与 2D:4D 比值之间以及 LPTS 与双手的 2D:4D 比值之间也存在显著负相关（对于男性：MPTS 左 vs. 右：P < 0.001，r = -0.607 vs. P < 0.001，r = -0.540）（对于男性：LPTS 左 vs. 右：P < 0.001，r = 0.451 vs. P < 0.001，r = 0.406）（对于女性：MPTS 左 vs. 右：P < 0.001，r = -0.638 vs. P < 0.001，r = -0.446）（对于女性：LPTS 左 vs. 右：P < 0.001，r = 0.618 vs. P < 0.001，r = 0.403）。
结论
2D:4D 比值，一种指示宫内睾酮-雌激素平衡的指标，与 PTS 有关。睾酮对胫骨近端生长板的影响可能是决定 PTS 值的因素之一。
证据水平
III 级回顾性比较研究。
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