基于青光眼旁萎缩形态的高度近视视网膜微循环分布。

Distribution of the Retinal Microcirculation Based on the Morphology of Peripapillary Atrophy in High Myopia.

机构信息

Department of Ophthalmology, Hunan Children's Hospital, Changsha, China,

Aier Eye Hospital Group, Changsha, China.

出版信息

Ophthalmic Res. 2023;66(1):1085-1095. doi: 10.1159/000531509. Epub 2023 Jul 17.

DOI:10.1159/000531509

PMID:37459845

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10614452/

Abstract

INTRODUCTION

The objective of this study was to evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy (PPA) deformation, and assess and identify the PPA morphology changes during the development of HM.

METHODS

One hundred sixty-seven right eyes from 167 HM patients were enrolled in this cross-sectional study. Using the optical coherence tomography angiography (OCTA) and fundus camera, we evaluated the following parameters: radian and type of PPA, intrapapillary vascular density (IVD), peripapillary vascular density (PVD), macular vascular density (MVD), and foveal avascular zone (FAZ). Based on the PPA radian, subjects were divided into four groups: the non-PPA, temporal PPA, advanced PPA, and annular PPA. At the same time, the above parameters were compared between the groups using analysis of variance (ANOVA) and least significant difference test.

RESULTS

Total enrolled patients were divided into the non-PPA group (22 eyes), temporal-PPA group (70 eyes), advanced-PPA group (60 eyes), and annular-PPA group (15 eyes). The results showed that the PVD in the annular-PPA group was smaller than that in the non-PPA group, especially in the superonasal, nasosuperior, nasoinferior, inferotemporal, temporoinferior, and superotemporal directions (F = 4.059, 5.014, 2.830, 4.798, 5.892, 3.439; p < 0.05). Notably, the PVD showcased the highest value in temporal, followed by that in superior and inferior, and the lowest in the nasal. Concerning the fovea deep macular vascular density, FAZ area, and subfoveal choroidal thickness in the annular-PPA group, they were less than those of the rest of the groups (p < 0.05).

CONCLUSION

The retinal microvasculature differed significantly in HM according to the PPA morphology. In addition to PVD and SFCT, the PPA can also affect FAZ. Finally, we speculated that PVD demonstrated better predictability of myopic progression than MVD.

摘要

简介

本研究旨在评估高度近视（HM）患者视盘和黄斑区的视网膜微血管，并探讨血管参数与视盘旁萎缩（PPA）变形之间的关系，评估并识别 HM 发展过程中 PPA 形态的变化。

方法

本横断面研究纳入了 167 例 HM 患者的 167 只右眼。使用光学相干断层扫描血管造影（OCTA）和眼底照相机评估以下参数：PPA 弧度和类型、视盘内血管密度（IVD）、视盘旁血管密度（PVD）、黄斑区血管密度（MVD）和中心凹无血管区（FAZ）。根据 PPA 弧度，将受试者分为四组：非 PPA 组、颞侧 PPA 组、进展性 PPA 组和环形 PPA 组。同时，使用方差分析（ANOVA）和最小显著差异检验比较各组之间的上述参数。

结果

总入组患者分为非 PPA 组（22 只眼）、颞侧 PPA 组（70 只眼）、进展性 PPA 组（60 只眼）和环形 PPA 组（15 只眼）。结果显示，环形 PPA 组的 PVD 小于非 PPA 组，尤其是在超鼻上、鼻上、鼻下、颞下、颞下和上颞方向（F = 4.059、5.014、2.830、4.798、5.892、3.439；p < 0.05）。值得注意的是，PVD 在颞侧最高，其次是上侧和下侧，鼻侧最低。环形 PPA 组的黄斑中心凹下深层血管密度、FAZ 面积和脉络膜厚度均小于其他组（p < 0.05）。