Centro de Biocombustibles y Bioproductos, Instituto Tecnológico Agrario de Castilla y León (ITACyL), Polígono Agroindustrial del Órbigo p. 2-6, Villarejo de Órbigo, León 24358, Spain.
Centro de Biocombustibles y Bioproductos, Instituto Tecnológico Agrario de Castilla y León (ITACyL), Polígono Agroindustrial del Órbigo p. 2-6, Villarejo de Órbigo, León 24358, Spain.
Bioresour Technol. 2023 Oct;386:129493. doi: 10.1016/j.biortech.2023.129493. Epub 2023 Jul 17.
Polyhydroxyalkanoates (PHAs) are considered an alternative to fossil fuel-based plastics. However, in spite of their interesting properties and their multiple applications, PHAs have not taken off as an industrial development. The reason is mainly due to the associated high-production costs, which represent a significant constraint. In recent years, the interest in lignocellulosic biomass (LCB) derived from crop, forestry or municipal waste by-products has been growing, since LCB is plentiful, cheap, renewable and sustainable. On this matter, the valorization of LCB into PHAs represents a promising route within circular economy strategies. However, much effort still needs to be made to improve the bioconversion yields and to enhance PHA production efficiency. So, this review focuses on reviewing the different options for PHA synthesis from LCB, stressing the progress in biomass deconstruction, enzymatic hydrolysis and microbial conversion. In addition, some of the current biological strategies for improving the process of bioconversion are discussed.
聚羟基脂肪酸酯（PHAs）被认为是一种替代基于化石燃料的塑料的材料。然而，尽管它们具有有趣的性质和多种应用，PHA 并没有像工业发展那样得到普及。原因主要是由于相关的高生产成本，这是一个重大的限制。近年来，人们对来源于农作物、林业或城市废物副产物的木质纤维素生物质（LCB）的兴趣日益增长，因为 LCB 丰富、廉价、可再生和可持续。在这方面，将 LCB 转化为 PHAs 代表了循环经济策略中很有前途的途径。然而，仍需要做出很大的努力来提高生物转化产率和增强 PHA 生产效率。因此，本综述重点讨论了从 LCB 合成 PHA 的不同选择，强调了生物质解构、酶解和微生物转化方面的进展。此外，还讨论了一些当前用于改善生物转化过程的生物学策略。
