Motoe T
Nihon Seikeigeka Gakkai Zasshi. 1986 May;60(5):495-509.
Architecture of the annulus fibrosus of the lumbar intervertebral disc in 49 human cadavers (30 fetuses and 19 adults) was observed topographically by polarized light microscopy to investigate the developmental process and the degenerative changes. At the 6th month of fetal life, the anterior annulus fibrosus presented a regular lamellar structure, while the posterior annulus fibrosus presented an irregular reticular structure. Difference of the interstriation angles of collagen fibers in the lamellae between the anterior and posterior annulus fibrosus was identified, and rather smaller angles were found in the anterior than in the posterior. At the 40's years of life collagen fibers in the lamellae showed loosening, separation and a cyst-like cavity, which finally developed into an annular tear. These degenerative changes observed predominantly in the posterior annulus fibrosus suggest that the posterior annulus fibrosus has structural and developmental instability against mechanical stress.
通过偏振光显微镜对49具人类尸体（30例胎儿和19例成人）腰椎间盘纤维环结构进行了局部观察，以研究其发育过程和退变情况。在胎儿期第6个月时，前纤维环呈现规则的板层结构，而后纤维环呈现不规则的网状结构。在前、后纤维环的板层中，胶原纤维的条纹间角度存在差异，前纤维环中的角度比后纤维环中的角度小。在40岁左右时，板层中的胶原纤维出现松弛、分离及囊样腔隙，最终发展为环形撕裂。这些主要在后纤维环观察到的退变变化表明，后纤维环在抵抗机械应力方面具有结构和发育上的不稳定性。
