Singh Sonia K, McCullough Louise
McGovern Medical School, UTHealth Houston, Houston, TX, USA.
Handb Exp Pharmacol. 2023;282:77-106. doi: 10.1007/164_2023_682.
There are differences in the prevalence and strength of risk factors in women, along with sex-specific risk factors such as pregnancy. Women have a higher lifetime risk of stroke compared to men, with worse outcomes including higher rates of death and disability. We have made strides in the identification of sex-specific risk factors but with the paucity of sex-specific end points in clinical trials, stroke treatment and research are hindered.
女性中风风险因素的患病率和强度存在差异,同时还有诸如怀孕等特定性别的风险因素。与男性相比,女性一生中患中风的风险更高,其后果更严重,包括更高的死亡率和致残率。我们在识别特定性别的风险因素方面取得了进展,但由于临床试验中缺乏特定性别的终点指标,中风治疗和研究受到了阻碍。