Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Curr Drug Res Rev. 2024;16(3):268-288. doi: 10.2174/2589977515666230717120828.
Valsartan is an orally active non-peptide angiotensin receptor antagonist, an effective and well-tolerated anti-hypertensive drug. Besides its antihypertensive action, it has clinical implications in many other disorders, like heart failure (HF), arrhythmia, chronic kidney disease (CKD), diabetic complications (DM), atherosclerosis, etc. Besides angiotensin receptor blocking activity, valsartan reduces circulating levels of biochemical markers, such as hs-CRP, which is responsible for its anti-inflammatory and anti-oxidant activity. Moreover, valsartan also acts by inhibiting or inducing various signalling pathways, such as inducing autophagy the AKT/mTOR/S6K pathway or inhibiting the TLR/NF-kB pathway. The current review exhaustively discusses the therapeutic implications of valsartan with specific emphasis on the mechanism of action in various disorders. The article provides a detailed spectrum of the therapeutic profile of valsartan and will likely be very useful to researchers working in the relevant research areas.
缬沙坦是一种口服有效的非肽类血管紧张素受体拮抗剂，是一种有效且耐受性良好的抗高血压药物。除了降压作用外，它在许多其他疾病中也具有临床意义，如心力衰竭（HF）、心律失常、慢性肾脏病（CKD）、糖尿病并发症（DM）、动脉粥样硬化等。除了血管紧张素受体阻断作用外，缬沙坦还可降低 hs-CRP 等生化标志物的循环水平，这与其抗炎和抗氧化活性有关。此外，缬沙坦还通过抑制或诱导各种信号通路发挥作用，如诱导自噬、AKT/mTOR/S6K 通路或抑制 TLR/NF-kB 通路。本文详细讨论了缬沙坦的治疗意义，特别强调了其在各种疾病中的作用机制。本文提供了缬沙坦治疗谱的详细信息，可能对从事相关研究领域的研究人员非常有用。
