P027：炎症性肠病患者的脑雾及其与益生菌使用的关联

P027 Brain Fog in Patients With Inflammatory Bowel Disease, and Association With Use of Probiotics.

作者信息

Dadlani Apaar, Gala Khushboo, Rai Jayesh, Rai Shesh, Dryden Gerald

机构信息

University Of Louisville, Louisville, Kentucky, United States.

Mayo Clinic Rochester, Rochester, Minnesota, United States.

出版信息

Am J Gastroenterol. 2021 Dec 1;116(Suppl 1):S7. doi: 10.14309/01.ajg.0000798708.22025.c0.

DOI:10.14309/01.ajg.0000798708.22025.c0

PMID:37461946

Abstract

BACKGROUND

Brain fog has been minimally studied in patients with inflammatory bowel disease (IBD). IBD patients frequently consume probiotics, whether sanctioned by a physician or not. However, probiotic consumption in itself has been shown to increase the incidence of brain fog. We aimed to study the association between brain fog in IBD patients with or without probiotic use.

METHODS

We conducted a cross-sectional study among patients visiting a busy IBD clinic. Patients aged >18 with a biopsy-proven diagnosis of inflammatory bowel disease, without pre-existing psychiatric illness or current use of opioid medications were included. They were divided into 2 groups: those using probiotics and those who did not. Patients were given a questionnaire that included details about symptoms of brain fog. Groups were analyzed by chi-square test for differences in baseline demographics, and Mann Whitney U test to compare outcomes between groups. A p-value < 0.05 was considered statistically significant.

RESULTS

Of the 66 patients included (mean age 44±2 years), 35 (53%) were female and 59 (89.4%) were Caucasian. Among these patients, 31.8% (n = 21) took probiotics as dietary supplements with the majority (67%, n = 14) taking probiotics for over a year. Overall, there was a trend for an association between probiotic use and brain fog in all patients (p = 0.080) but no statistical significance was attained. However, brain fog was significantly associated with probiotic use among Caucasian patients (p = 0.044). Furthermore, there was a statistically significant association between brain fog and male patients using probiotics (p = 0.004). Duration of probiotic use was also associated with brain fog (p = 0.038).

CONCLUSION

Consumption of probiotics was independently associated with brain fog in men, as well as Caucasian patients with IBD respectively. Given the high prevalence of probiotic use in IBD patients, prospective studies are warranted to examine the causal relationship between probiotics and IBD-associated brain fog to guide prescription of probiotic supplements for IBD.

摘要

背景

关于炎症性肠病（IBD）患者的脑雾现象研究极少。IBD患者经常食用益生菌，无论是否有医生的许可。然而，已表明食用益生菌本身会增加脑雾的发生率。我们旨在研究使用或未使用益生菌的IBD患者中脑雾之间的关联。

方法

我们在一家繁忙的IBD诊所就诊的患者中进行了一项横断面研究。纳入年龄大于18岁、经活检证实患有炎症性肠病、无既往精神疾病或目前未使用阿片类药物的患者。他们被分为两组：使用益生菌的患者和未使用益生菌的患者。向患者发放了一份问卷，其中包括有关脑雾症状的详细信息。通过卡方检验分析两组在基线人口统计学方面的差异，并使用曼-惠特尼U检验比较两组之间的结果。p值<0.05被认为具有统计学意义。

结果

纳入的66例患者（平均年龄44±2岁）中，35例（53%）为女性，59例（89.4%）为白种人。在这些患者中，31.8%（n = 21）将益生菌作为膳食补充剂服用，大多数（67%，n = 14）服用益生菌超过一年。总体而言，所有患者中使用益生菌与脑雾之间存在关联趋势（p = 0.080），但未达到统计学意义。然而，在白种人患者中，脑雾与使用益生菌显著相关（p = 0.044）。此外，脑雾与使用益生菌的男性患者之间存在统计学显著关联（p = 0.004）。益生菌的使用时长也与脑雾相关（p = 0.038）。