Hershfinkel Michal
Department of Physiology and Cell Biology and the School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Physiol. 2024 Apr;602(8):1579-1594. doi: 10.1113/JP283834. Epub 2023 Jul 18.
Zinc is essential for many physiological functions, with a major role in digestive system, skin health, and learning and memory. On the cellular level, zinc is involved in cell proliferation and cell death. A selective zinc sensing receptor, ZnR/GPR39 is a Gq-coupled receptor that acts via the inositol trisphosphate pathway to release intracellular Ca. The ZnR/GPR39 serves as a mediator between extracellular changes in Zn concentration and cellular Ca signalling. This signalling pathway regulates ion transporters activity and thereby controls the formation of transepithelial gradients or neuronal membrane potential, which play a fundamental role in the physiological function of these tissues. This review focuses on the role of Ca signalling, and specifically ZnR/GPR39, with respect to the regulation of the Na/H exchanger, NHE1, and of the K/Cl cotransporters, KCC1-3, and also describes the physiological implications of this regulation.
锌对许多生理功能至关重要，在消化系统、皮肤健康以及学习和记忆方面发挥着主要作用。在细胞水平上，锌参与细胞增殖和细胞死亡。一种选择性锌感应受体ZnR/GPR39是一种与Gq偶联的受体，它通过肌醇三磷酸途径发挥作用以释放细胞内的钙。ZnR/GPR39作为细胞外锌浓度变化与细胞钙信号传导之间的介质。该信号通路调节离子转运体活性，从而控制跨上皮梯度或神经元膜电位的形成，这些在这些组织的生理功能中起着基本作用。本综述重点关注钙信号传导的作用，特别是ZnR/GPR39在调节钠/氢交换体NHE1和钾/氯共转运体KCC1 - 3方面的作用，并描述了这种调节的生理意义。
