Bertolotto A, Magrassi M L, Orsi L, Sitia C, Schiffer D
J Neurooncol. 1986;4(1):43-8. doi: 10.1007/BF02158001.
Glycosaminoglycans (GAGs) were isolated, separated by electrophoresis and quantified in 36 neurosurgical specimens of human gliomas and in 8 samples of normal white and gray matter. Gliomas of various degrees of malignancy exhibited different GAG patterns. Total GAG concentration was three times higher in low grade gliomas than in normal white matter. The mean percentage of single GAG classes was usually similar in both tissues, although in certain tumor samples a higher percentage of hyaluronate was found. GAG patterns in anaplastic astrocytomas, however, more closely resembled normal white and gray matter, both quantitatively and qualitatively. Glioblastomas, on the other hand, showed high GAG concentrations, in particular of heparan sulfate and dermatan sulfate. This finding could be secondary to the abundant vessels and mesodermal material associated with this oncotype. The hyaluronate/sulfated GAGs ratio was lower in oligodendrogliomas than in low grade astrocytomas. This biochemical feature may be correlated with the alcianophilia found in the honey-comb degeneration of oligodendrogliomas. The significance of these findings as they relate to tumor histology and biology have been discussed.
从36例人类神经胶质瘤的神经外科标本以及8例正常白质和灰质样本中分离、电泳分离并定量分析了糖胺聚糖（GAGs）。不同恶性程度的神经胶质瘤表现出不同的GAG模式。低级别神经胶质瘤中的总GAG浓度比正常白质高两倍。尽管在某些肿瘤样本中发现透明质酸的百分比更高，但两种组织中单个GAG类别的平均百分比通常相似。然而，间变性星形细胞瘤中的GAG模式在数量和质量上更类似于正常白质和灰质。另一方面，胶质母细胞瘤显示出高GAG浓度，尤其是硫酸乙酰肝素和硫酸皮肤素。这一发现可能继发于与这种肿瘤类型相关的丰富血管和中胚层物质。少突胶质细胞瘤中的透明质酸/硫酸化GAGs比值低于低级别星形细胞瘤。这种生化特征可能与少突胶质细胞瘤蜂窝状变性中发现的阿利新蓝嗜色性有关。已经讨论了这些发现与肿瘤组织学和生物学相关的意义。
