Engelhardt A
Acta Neuropathol. 1980;49(3):199-203. doi: 10.1007/BF00707107.
Acid mucopolysaccharides (glycosaminoglycans) are identified by histochemical methods in biopsies of 107 human brain tumors. Isomorphous oligodendrogliomas and astrocytomas stained with alcian blue show marked, weblike, or diffuse distribution and concentration of acid mucopolysaccharides. Histochemically, the characteristics of hyaluronic acid and chondroitin sulphate are found. They seem to be closely associated with the cytoplasmic membrane of the tumor cells. Increased dedifferentiation and malignancy lead to a progressive loss of alcianophilia. In tumors such as ependymomas, meningiomas, sarcomas, and medulloblastomas, concentration of alcian blue is found only in the blood vessel walls and connective tissue. In neurinomas a greater amount of acid mucopolysaccharides can be shown not only in the collagen fibers but also in tumor areas of the Antoni-B-type. One case of cerebral neuroblastoma revealed marked alcianophilia of the parenchyma and stroma. As with findings in experimental brain tumors, an altered regulation of the carbohydrate metabolism of the glia cells during neoplastic transformation is discussed as a reason for the alcianophilia of gliomas.
通过组织化学方法在107例人脑肿瘤活检标本中鉴定出酸性粘多糖（糖胺聚糖）。用阿尔辛蓝染色的同形少突胶质细胞瘤和星形细胞瘤显示出酸性粘多糖的显著、网状或弥漫性分布及聚集。组织化学上，发现了透明质酸和硫酸软骨素的特征。它们似乎与肿瘤细胞的细胞质膜密切相关。去分化和恶性程度增加导致阿尔辛蓝嗜色性逐渐丧失。在室管膜瘤、脑膜瘤、肉瘤和髓母细胞瘤等肿瘤中，仅在血管壁和结缔组织中发现阿尔辛蓝聚集。在神经鞘瘤中，不仅在胶原纤维中，而且在Antoni-B型肿瘤区域都能显示出大量酸性粘多糖。1例脑成神经细胞瘤显示实质和间质有明显的阿尔辛蓝嗜色性。与实验性脑肿瘤的发现一样，肿瘤转化过程中胶质细胞碳水化合物代谢的调节改变被认为是胶质瘤嗜阿尔辛蓝的原因。
