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在一家三级护理中心的肾移植患者中平均暖缺血时间:一项描述性的横断面研究。

Mean Warm Ischemia Time among Kidney Transplant Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

机构信息

Department of Nephrology, Shahid Dharmabhakta National Transplant Center, Dudhpati, Bhaktapur, Nepal.

Department of Transplant Surgery, Shahid Dharmabhakta National Transplant Center, Dudhpati, Bhaktapur, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Jun 1;61(262):519-521. doi: 10.31729/jnma.8190.

DOI:10.31729/jnma.8190
PMID:37464848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10276949/
Abstract

INTRODUCTION

In renal transplantation, warm ischemia time is the interval from the removal of a procured kidney from ice storage to initiating graft reperfusion. Successful kidney transplantation depends on warm ischemia time. The study aims to find the mean warm ischemia time among kidney transplant patients in a tertiary care centre.

METHODS

This descriptive cross-sectional study was conducted among kidney transplant patients in a tertiary care centre. Data from 15 December 2012 to 15 October 2022 were collected between 1 December 2022 to 4 January 2023 from the hospital records. Ethical approval was taken from the Nepal Health Research Council (Reference number: 1341). All first-time living-related kidney transplant recipients were included in the study. All the patients undergoing kidney transplants from brain-dead donors were excluded from the study. Convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated.

RESULTS

Among 230 patients, the mean warm ischemia time was 35.45±7.35 min. The mean first warm ischemia time was 4.28±2.05 min and the mean second warm ischemia time was 31.27±7.04 min. The mean age of the recipients was 35.14±10.49 years (range 14-64), of which 173 (75.20%) were male and 57 (24.80%) were female.

CONCLUSIONS

The mean warm ischemia time among kidney transplant patients in a tertiary care centre was similar to the studies done in similar settings.

KEYWORDS

kidney transplantation; prevalence; warm ischemia.

摘要

介绍

在肾移植中,热缺血时间是从从冰存中取出供肾到开始移植物再灌注的间隔时间。成功的肾移植取决于热缺血时间。本研究旨在确定三级保健中心肾移植患者的平均热缺血时间。

方法

这是一项在三级保健中心进行的肾移植患者描述性横断面研究。数据收集于 2022 年 12 月 1 日至 2023 年 1 月 4 日,来自 2012 年 12 月 15 日至 2022 年 10 月 15 日的医院记录。本研究已获得尼泊尔健康研究委员会的伦理批准(编号:1341)。所有首次接受活体亲属肾移植的患者均纳入本研究。所有接受脑死亡供者肾移植的患者均排除在本研究之外。采用便利抽样法。计算了点估计值和 95%置信区间。

结果

在 230 名患者中,平均热缺血时间为 35.45±7.35 分钟。平均第一次热缺血时间为 4.28±2.05 分钟,第二次热缺血时间为 31.27±7.04 分钟。受者的平均年龄为 35.14±10.49 岁(范围 14-64 岁),其中 173 名(75.20%)为男性,57 名(24.80%)为女性。

结论

三级保健中心肾移植患者的平均热缺血时间与类似环境下的研究相似。

关键词

肾移植;患病率;热缺血。

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本文引用的文献

1
Global Perspective on Kidney Transplantation: China.全球肾脏移植视角:中国
Kidney360. 2021 Nov 12;3(2):364-367. doi: 10.34067/KID.0003302021. eCollection 2022 Feb 24.
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Warm Ischemia Time at Vascular Anastomosis is an Independent Predictor for Delayed Graft Function in Kidney Transplant Recipients.血管吻合口的热缺血时间是移植肾延迟功能恢复的独立预测因子。
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Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation.长时间的热缺血时间与肾移植后的移植物功能衰竭及死亡率相关。
Kidney Int. 2016 Mar;89(3):648-58. doi: 10.1016/j.kint.2015.09.002. Epub 2015 Dec 30.
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Laparoscopic kidney donation - giving in the best way possible.腹腔镜活体肾捐赠——以尽可能最佳的方式奉献。
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Comparison of the right and left laparoscopic live donor nephrectomies: a clinical case load.右腹腔镜与左腹腔镜活体供肾切除术的比较:临床病例量。
Eur Rev Med Pharmacol Sci. 2013 May;17(10):1389-94.
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The impact of vascular anastomosis time on early kidney transplant outcomes.血管吻合时间对肾移植早期结局的影响。
Transplant Res. 2013 May 15;2(1):8. doi: 10.1186/2047-1440-2-8.
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KHA-CARI guideline: recipient assessment for transplantation.KHA-CARI指南:移植受者评估
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Deleterious influence of prolonged warm ischemia in living donor kidney transplantation.活体供肾移植中长时间热缺血的有害影响。
Transplant Proc. 2012 Jun;44(5):1222-6. doi: 10.1016/j.transproceed.2012.01.118.
9
Warm ischemia less than 30 minutes is not necessarily safe during partial nephrectomy: every minute matters.在部分肾切除术中,30 分钟以内的热缺血时间不一定安全:每一分钟都很重要。
Urol Oncol. 2011 Nov-Dec;29(6):826-8. doi: 10.1016/j.urolonc.2011.02.015.
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Assessing the impact of ischaemia time during partial nephrectomy.评估部分肾切除术期间缺血时间的影响。
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