Institute of Robotics, Shanghai Jiao Tong University, Shanghai 200240, China.
Department of Neurosurgery of Huashan Hospital, Fudan University, Shanghai 200040, China.
Cereb Cortex. 2023 Aug 23;33(17):9764-9777. doi: 10.1093/cercor/bhad242.
Making hand movements in response to visual cues is common in daily life. It has been well known that this process activates multiple areas in the brain, but how these neural activations progress across space and time remains largely unknown. Taking advantage of intracranial electroencephalographic (iEEG) recordings using depth and subdural electrodes from 36 human subjects using the same task, we applied single-trial and cross-trial analyses to high-frequency iEEG activity. The results show that the neural activation was widely distributed across the human brain both within and on the surface of the brain, and focused specifically on certain areas in the parietal, frontal, and occipital lobes, where parietal lobes present significant left lateralization on the activation. We also demonstrate temporal differences across these brain regions. Finally, we evaluated the degree to which the timing of activity within these regions was related to sensory or motor function. The findings of this study promote the understanding of task-related neural processing of the human brain, and may provide important insights for translational applications.
在日常生活中，人们常对手部的视觉线索做出反应。众所周知，这一过程会激活大脑中的多个区域，但这些神经活动如何在空间和时间上展开仍然知之甚少。我们利用 36 名人类被试者使用深度和硬膜下电极进行的颅内脑电图 (iEEG) 记录，应用单次和跨次分析方法对高频 iEEG 活动进行了研究。结果表明，神经激活在大脑内部和表面广泛分布，特别集中在顶叶、额叶和枕叶的某些区域，其中顶叶的激活存在显著的左侧偏侧化。我们还展示了这些脑区之间的时间差异。最后，我们评估了这些区域内活动的时间与感觉或运动功能之间的关系程度。本研究的发现促进了对人类大脑与任务相关的神经处理的理解，并且可能为转化应用提供重要的见解。
