Rosenfeld R G, Wilson D M, Lee P D, Hintz R L
J Pediatr. 1986 Sep;109(3):428-33. doi: 10.1016/s0022-3476(86)80112-3.
Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level less than 7 ng/ml), 44 normal short children, and 197 children with normal height were assayed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.
采用特异性放射免疫分析法，对68例生长激素（GH）缺乏儿童（激发试验血清GH水平低于7 ng/ml）、44例正常身材矮小儿童及197例身高正常儿童的血浆样本进行了生长调节素肽、胰岛素样生长因子（IGF）-I和-II的检测。18%的GH缺乏儿童IGF-I水平在同龄人正常范围内，而32%的正常身材矮小儿童IGF-I水平较低。52%的GH缺乏儿童IGF-II水平较低，但正常身材矮小儿童中这一比例为35%。然而，仅有4%的GH缺乏儿童血浆IGF-I和IGF-II水平均正常。此外，仅有0.5%的正常儿童和11%的正常身材矮小儿童血浆IGF-I和IGF-II水平均较低。我们得出结论，GH缺乏儿童和正常身材矮小儿童的血浆IGF-I或IGF-II水平存在重叠，但放射免疫分析法联合使用可能有助于更好地区分正常儿童、正常身材矮小儿童和GH缺乏儿童。
