Department of Endocrinology, Qingdao University, Qingdao, China.
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
J Clin Hypertens (Greenwich). 2021 Jun;23(6):1112-1119. doi: 10.1111/jch.14249. Epub 2021 Apr 1.
The relationship between insulin-like growth factor-1 (IGF-1) and systolic blood pressure (SBP) is controversial in adults and children. The purpose of this study was to investigate the relationship between the IGF-1 standard deviation score (IGF-1 SDS) and SBP in children with short stature. A cross-sectional analysis including 1315 children with short stature was conducted from March 2013 to October 2020. We estimated IGF-1, blood pressure and other laboratory tests, and anthropometric indicators were also evaluated. Subgroup analyses of the pubertal stage, sex, growth hormone levels, thyroid hormone levels, fasting blood glucose levels, and triglyceride levels were performed. A positive association between the IGF-1 SDS and SBP was observed by univariate analysis (p < .001). We further found a nonlinear association between the IGF-1 SDS and SBP. The inflection point for the curve was found at an IGF-1 SDS level of -2.91. In multivariate piecewise linear regression, there was a positive association between the IGF-1 SDS and SBP when the IGF-1 SDS was greater than -2.91 (β 1.56, 95% CI: 0.91, 2.22; p < .001). However, we did not observe a significant relationship between the IGF-1 SDS and SBP when the IGF-1 SDS level was less than -2.91 (β -0.95, 95% CI -3.17, 1.28; p = .379). This association was consistent across subgroup analyses. The present study demonstrated that there is a nonlinear relationship between the IGF-1 SDS and SBP in children with short stature. Increased serum IGF-1 levels were associated with elevated SBP when the IGF-1 levels reached the inflection point.
胰岛素样生长因子-1（IGF-1）与收缩压（SBP）之间的关系在成人和儿童中存在争议。本研究旨在探讨矮小儿童 IGF-1 标准差评分（IGF-1 SDS）与 SBP 的关系。2013 年 3 月至 2020 年 10 月进行了一项包括 1315 名矮小儿童的横断面分析。我们评估了 IGF-1、血压和其他实验室检查以及人体测量指标。进行了青春期阶段、性别、生长激素水平、甲状腺激素水平、空腹血糖水平和甘油三酯水平的亚组分析。单变量分析显示 IGF-1 SDS 与 SBP 呈正相关（p<0.001）。我们还发现 IGF-1 SDS 与 SBP 之间存在非线性关系。曲线的拐点出现在 IGF-1 SDS 水平为-2.91 时。在多元分段线性回归中，当 IGF-1 SDS 大于-2.91 时，IGF-1 SDS 与 SBP 呈正相关（β 1.56，95%CI：0.91，2.22；p<0.001）。然而，当 IGF-1 SDS 水平低于-2.91 时，我们没有观察到 IGF-1 SDS 与 SBP 之间的显著关系（β-0.95，95%CI-3.17，1.28；p=0.379）。这种关联在亚组分析中是一致的。本研究表明，矮小儿童 IGF-1 SDS 与 SBP 之间存在非线性关系。当 IGF-1 水平达到拐点时，血清 IGF-1 水平升高与 SBP 升高相关。
