Department of Sports Rehabilitation, Southwest Medical University, Luzhou, China.
Department of Clinical Medicine, Southwest Medical University, Luzhou, China.
J Med Virol. 2023 Jul;95(7):e28950. doi: 10.1002/jmv.28950.
With the rapid increase in the incidence of cervical cancer, anal cancer and other cancers, human papillomavirus (HPV) infection has become a growing concern. Persistent infection with high-risk HPV is a major cause of malignant tumors. In addition, microbiota and viruses such as human immunodeficiency virus, herpes simplex virus, and Epstein-Barr virus are closely associated with HPV infection. The limited effectiveness of existing treatments for HPV-associated tumors and the high rates of recurrence and metastasis in patients create an urgent need for novel and effective approaches. In recent years, HPV vaccine coverage has increased and can reduce the incidence of serious adverse events. Overall, this article provides a comprehensive overview of HPV biology, microbiome, and other viral interactions in cancer development, highlighting the need for a more comprehensive approach to cancer prevention and treatment. Current and emerging HPV-related cancer control and treatment strategies are also further explored.
随着宫颈癌、肛门癌等癌症发病率的迅速上升，人乳头瘤病毒（HPV）感染已成为人们日益关注的问题。高危型 HPV 的持续感染是恶性肿瘤的主要病因。此外，微生物群和人类免疫缺陷病毒、单纯疱疹病毒和爱泼斯坦-巴尔病毒等病毒与 HPV 感染密切相关。现有的 HPV 相关肿瘤治疗方法效果有限，患者的复发和转移率高，这就迫切需要新的、有效的治疗方法。近年来，HPV 疫苗的接种率有所提高，可降低严重不良事件的发生率。总的来说，本文全面概述了 HPV 生物学、微生物组和其他病毒在癌症发展中的相互作用，强调了需要采取更全面的癌症预防和治疗方法。本文还进一步探讨了当前和新兴的 HPV 相关癌症防控和治疗策略。
