在光氧化还原催化下，使用α-芳氧基喹核铵盐和腈对苄基和环烷烃C(sp³)-H键供体进行氧化亚胺化反应
Oxidative Imidation of Benzylic and Cycloalkane C(sp)-H Bond Donors Using -Aroyloxyquinuclidinium Salts and Nitriles under Photoredox Catalysis.
作者信息
Hitt Michael, Norris Andrew, Vedernikov Andrei N
机构信息
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
出版信息
Org Lett. 2023 Jul 28;25(29):5504-5508. doi: 10.1021/acs.orglett.3c01966. Epub 2023 Jul 19.
PMID:37467385
Abstract
A series of -aroyloxyquinuclidinium salts were prepared and used as reagents to perform efficient three-component Ritter-Mumm-type oxidative C-H imidation of donors of 1° and 2° benzylic C-H bonds used as limiting reagents with nitriles as a source of imide nitrogen under photocatalytic conditions; these reagents also exhibit somewhat lower reactivity toward cycloalkanes.
摘要
制备了一系列芳氧基喹核盐，并用作试剂，在光催化条件下，将作为限量试剂的一级和二级苄基C-H键供体与作为酰亚胺氮源的腈进行高效的三组分里特-穆姆型氧化C-H亚胺化反应；这些试剂对环烷烃的反应活性也略低。
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