Biological Inorganic Chemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, United Kingdom.
Biological Inorganic Chemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, United Kingdom.
Curr Opin Microbiol. 2023 Oct;75:102347. doi: 10.1016/j.mib.2023.102347. Epub 2023 Jul 17.
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.
抗菌药物耐药性（AMR）负担日益加重，是全球公共卫生面临的最令人担忧的威胁之一。由于经济激励措施不足，临床研发管道中新药物的供应不断减少，因此迫切需要更具创新性的新型药物设计和开发方法。基于金属的化合物正迅速成为有机药物的替代品，因为它们具有通过特定于金属的作用模式杀死病原体的能力。本文综述了近年来基于金属的抗菌剂的最新进展，包括金属配合物、金属离子和催化金属药物。本文最后展望了基于金属的抗生素的合理设计，以及如何利用其独特性质来解决 AMR 问题。
